Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/58955
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dc.contributor.authorKorkmaz, Ece-
dc.contributor.authorGurses, Dolunay-
dc.contributor.authorCetin, Gokhan-
dc.contributor.authorSenol, Hande-
dc.date.accessioned2025-02-20T19:13:20Z-
dc.date.available2025-02-20T19:13:20Z-
dc.date.issued2025-
dc.identifier.issn1047-9511-
dc.identifier.issn1467-1107-
dc.identifier.urihttps://doi.org/10.1017/S1047951124025903-
dc.identifier.urihttps://hdl.handle.net/11499/58955-
dc.description.abstractIntroduction: Acute rheumatic fever commonly causes carditis in children. It is critical to have biomarkers for diagnostic and prognostic purposes. We aimed to investigate the expressions of miR-101, miR-1183, and miR-1299 in children with acute rheumatic fever and rheumatic heart disease and determine their potential as diagnostic biomarkers. Methods: This cross-sectional study was conducted on 69 paediatric acute rheumatic fever patients and 27 gender and age-matched controls. The clinical findings were noted from medical records, echocardiography was repeated, and plasma miR-101, miR-1183, and miR-1299 expressions were studied using RT-PCR. Results: Out of 54 patients with carditis, 36 developed rheumatic heart disease with significant left-sided heart involvement. No significant demographic difference was present between rheumatic heart disease patients and controls (p > 0.05). miR-101 and miR-1183 expressions significantly reduced by 4.5-fold in acute rheumatic fever patients compared to controls (p : 0.029 and p : 0.024, respectively). Family history was found to be significantly associated with 9-fold reduced miR-1183 expression in acute rheumatic fever patients (p : 0.005). The expression of miR-1183 in acute rheumatic fever children with carditis in general and severe carditis was significantly reduced 4.5- and 9-fold, respectively (p : 0.024 and p : 0.007, respectively). In acute rheumatic fever cases with moderate-severe carditis and patients who did not develop rheumatic heart disease, miR-1183 expression significantly reduced 8.3-fold and 9-fold, respectively (p : 0.015 and p : 0.019, respectively). The ROC analysis revealed that miR-101 and miR-1183 were statistically significant for acute rheumatic fever diagnosis (AUC: 0.64 for both miRNAs). Conclusions: Significantly lower plasma expressions of miR-101 and miR-1183 in acute rheumatic fever patients, especially in cases with moderate-severe carditis, might indicate the potential use of these miRNAs as diagnostic biomarkers.en_US
dc.language.isoenen_US
dc.publisherCambridge Univ Pressen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute Rheumatic Feveren_US
dc.subjectRheumatic Heart Diseaseen_US
dc.subjectMirnaen_US
dc.subjectCarditisen_US
dc.titleThe roles of miR-101, miR-1183 and miR-1299 in acute rheumatic fever and rheumatic heart diseaseen_US
dc.typeArticleen_US
dc.departmentPamukkale Universityen_US
dc.identifier.doi10.1017/S1047951124025903-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.authorscopusid59551437500-
dc.authorscopusid6603227515-
dc.authorscopusid14017831000-
dc.authorscopusid56345836900-
dc.identifier.pmid39895315-
dc.identifier.scopus2-s2.0-85217511360-
dc.identifier.wosWOS:001413523300001-
dc.identifier.scopusqualityQ3-
dc.description.woscitationindexScience Citation Index Expanded-
dc.identifier.wosqualityQ4-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.03. Basic Medical Sciences-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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