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https://hdl.handle.net/11499/58955
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Korkmaz, Ece | - |
dc.contributor.author | Gurses, Dolunay | - |
dc.contributor.author | Cetin, Gokhan | - |
dc.contributor.author | Senol, Hande | - |
dc.date.accessioned | 2025-02-20T19:13:20Z | - |
dc.date.available | 2025-02-20T19:13:20Z | - |
dc.date.issued | 2025 | - |
dc.identifier.issn | 1047-9511 | - |
dc.identifier.issn | 1467-1107 | - |
dc.identifier.uri | https://doi.org/10.1017/S1047951124025903 | - |
dc.identifier.uri | https://hdl.handle.net/11499/58955 | - |
dc.description.abstract | Introduction: Acute rheumatic fever commonly causes carditis in children. It is critical to have biomarkers for diagnostic and prognostic purposes. We aimed to investigate the expressions of miR-101, miR-1183, and miR-1299 in children with acute rheumatic fever and rheumatic heart disease and determine their potential as diagnostic biomarkers. Methods: This cross-sectional study was conducted on 69 paediatric acute rheumatic fever patients and 27 gender and age-matched controls. The clinical findings were noted from medical records, echocardiography was repeated, and plasma miR-101, miR-1183, and miR-1299 expressions were studied using RT-PCR. Results: Out of 54 patients with carditis, 36 developed rheumatic heart disease with significant left-sided heart involvement. No significant demographic difference was present between rheumatic heart disease patients and controls (p > 0.05). miR-101 and miR-1183 expressions significantly reduced by 4.5-fold in acute rheumatic fever patients compared to controls (p : 0.029 and p : 0.024, respectively). Family history was found to be significantly associated with 9-fold reduced miR-1183 expression in acute rheumatic fever patients (p : 0.005). The expression of miR-1183 in acute rheumatic fever children with carditis in general and severe carditis was significantly reduced 4.5- and 9-fold, respectively (p : 0.024 and p : 0.007, respectively). In acute rheumatic fever cases with moderate-severe carditis and patients who did not develop rheumatic heart disease, miR-1183 expression significantly reduced 8.3-fold and 9-fold, respectively (p : 0.015 and p : 0.019, respectively). The ROC analysis revealed that miR-101 and miR-1183 were statistically significant for acute rheumatic fever diagnosis (AUC: 0.64 for both miRNAs). Conclusions: Significantly lower plasma expressions of miR-101 and miR-1183 in acute rheumatic fever patients, especially in cases with moderate-severe carditis, might indicate the potential use of these miRNAs as diagnostic biomarkers. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Cambridge Univ Press | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Acute Rheumatic Fever | en_US |
dc.subject | Rheumatic Heart Disease | en_US |
dc.subject | Mirna | en_US |
dc.subject | Carditis | en_US |
dc.title | The roles of miR-101, miR-1183 and miR-1299 in acute rheumatic fever and rheumatic heart disease | en_US |
dc.type | Article | en_US |
dc.department | Pamukkale University | en_US |
dc.identifier.doi | 10.1017/S1047951124025903 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 59551437500 | - |
dc.authorscopusid | 6603227515 | - |
dc.authorscopusid | 14017831000 | - |
dc.authorscopusid | 56345836900 | - |
dc.identifier.pmid | 39895315 | - |
dc.identifier.scopus | 2-s2.0-85217511360 | - |
dc.identifier.wos | WOS:001413523300001 | - |
dc.identifier.scopusquality | Q3 | - |
dc.description.woscitationindex | Science Citation Index Expanded | - |
dc.identifier.wosquality | Q4 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | Article | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.03. Basic Medical Sciences | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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