Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5916
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dc.contributor.authorAvci, C.B.-
dc.contributor.authorYilmaz, S.-
dc.contributor.authorDogan, Z.O.-
dc.contributor.authorSaydam, G.-
dc.contributor.authorDodurga, Yavuz-
dc.contributor.authorEkiz, H.A.-
dc.contributor.authorKartal, M.-
dc.date.accessioned2019-08-16T12:03:12Z-
dc.date.available2019-08-16T12:03:12Z-
dc.date.issued2011-
dc.identifier.issn1024-5332-
dc.identifier.urihttps://hdl.handle.net/11499/5916-
dc.identifier.urihttps://doi.org/10.1179/102453311X13085644680104-
dc.description.abstractWe aimed to examine the growth suppressive effects of quercetin on acute promyelocytic and lymphoblastic leukemia and chronic myeloid leukemia, and to find out whether the growth suppression is related to the blocking of telomerase enzyme activity. Cytotoxic effects of quercetin were shown by trypan blue analyses. Apoptotic effects of quercetin were examined by acridine orange and ethidium bromide staining by fluorescence microscopy. The effects of quercetin on telomerase enzyme activity were shown by hTERT Quantification Kit. Our results demonstrated that quercetin has antiproliferative and apoptotic effects on T-cell acute lymphoblastic leukemia (ALL), acute promyelocytic leukemia, and chronic myeloid leukemia (CML) cells. We also showed for the first time by this study that quercetin suppresses the activity of telomerase in ALL and CML cells. The results of this study show the importance of quercetin for its therapeutic potential in treatment of leukemias. © W. S. Maney & Son Ltd 2011.en_US
dc.language.isoenen_US
dc.relation.ispartofHematologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectApoptosisen_US
dc.subjecthTERTen_US
dc.subjectLeukemiaen_US
dc.subjectQuercetinen_US
dc.subjectTelomeraseen_US
dc.subjectacridine orangeen_US
dc.subjectethidium bromideen_US
dc.subjectquercetinen_US
dc.subjecttelomerase reverse transcriptaseen_US
dc.subjecttrypan blueen_US
dc.subjectacute lymphoblastic leukemiaen_US
dc.subjectantineoplastic activityen_US
dc.subjectapoptosisen_US
dc.subjectarticleen_US
dc.subjectcancer inhibitionen_US
dc.subjectcell proliferationen_US
dc.subjectcell viabilityen_US
dc.subjectchronic myeloid leukemiaen_US
dc.subjectconcentration responseen_US
dc.subjectcontrolled studyen_US
dc.subjectdrug cytotoxicityen_US
dc.subjectdrug effecten_US
dc.subjectenzyme activityen_US
dc.subjectenzyme assayen_US
dc.subjectenzyme repressionen_US
dc.subjectfluorescence microscopyen_US
dc.subjecthumanen_US
dc.subjecthuman cellen_US
dc.subjectleukemia cellen_US
dc.subjectlymphatic leukemiaen_US
dc.subjectpriority journalen_US
dc.subjectpromyelocytic leukemiaen_US
dc.subjectAntineoplastic Agentsen_US
dc.subjectAntioxidantsen_US
dc.subjectCell Line, Tumoren_US
dc.subjectCell Survivalen_US
dc.subjectDose-Response Relationship, Drugen_US
dc.subjectEnzyme Activationen_US
dc.subjectGene Expression Regulation, Leukemicen_US
dc.subjectHL-60 Cellsen_US
dc.subjectHumansen_US
dc.subjectK562 Cellsen_US
dc.subjectRNA, Messengeren_US
dc.titleQuercetin-induced apoptosis involves increased hTERT enzyme activity of leukemic cellsen_US
dc.typeArticleen_US
dc.identifier.volume16en_US
dc.identifier.issue5en_US
dc.identifier.startpage303-
dc.identifier.startpage303en_US
dc.identifier.endpage307en_US
dc.authorid0000-0002-4936-5954-
dc.identifier.doi10.1179/102453311X13085644680104-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.pmid21902895en_US
dc.identifier.scopus2-s2.0-80052590432en_US
dc.identifier.wosWOS:000294495000008en_US
dc.identifier.scopusqualityQ1-
dc.ownerPamukkale University-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.openairetypeArticle-
crisitem.author.dept14.03. Basic Medical Sciences-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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