Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5939
Title: Intensive menstrual bleeding successfully treated with recombinant factor VIIa in glanzmann thrombasthenia
Authors: Balci, Y.I.
Karabulut, A.
Kabukcu, Sibel
Sari, Hakan İsmail
Keskin, A.
Keywords: deep venous thrombosis
endocrinology
venous thromboembolism
drospirenone plus ethinylestradiol
goserelin
recombinant blood clotting factor 7a
tranexamic acid
unclassified drug
zolodex
adult
apheresis
article
case report
drug efficacy
drug megadose
drug response
drug safety
drug withdrawal
erythrocyte transfusion
female
Glanzmann disease
human
menorrhagia
oral contraception
priority journal
thrombocyte transfusion
thromboembolism
treatment response
Factor VIIa
Female
Humans
Menorrhagia
Menstruation
Recombinant Proteins
Thrombasthenia
Young Adult
Abstract: Glanzmann thrombasthenia (GT) is a rare inherited qualitative platelet disorder due to the deficiency or defect of platelet membrane glycoprotein (GP) IIb/IIIa complex. Symptoms include purpura, petechiae, bruising, gingival bleeding, epistaxis, and menorrhagia. Platelet transfusion is considered the standard therapy for securing hemostasis in patients with GT when local measures and antifibrinolytic agents are inadequate. However, repeated platelet transfusions may result in GP IIb/IIIa and/or human leukocyte antigen (HLA) immunization and development of platelet refractoriness. Recombinant factor VIIa (rFVIIa) has been introduced as therapeutic alternative and has been suggested to be effective. Recombinant factor VIIa is indicated in Europe for the treatment of GT refractory of platelet transfusion. In previous studies, rFVIIa has been used in the prophylactic treatment of bleeding in patients with GT undergoing pelvic surgery, cesarean section, and vaginal delivery. In this article, we present a case of intensive menstrual bleeding refractory to previous antifibrinolytic agents and platelet transfusions but which responded well to treatment with rFVIIa. To our knowledge, there is no study or reported case in the literature reporting successful use of rFVIIa in a patient with excessive menstrual bleeding due to GT. © The Author(s) 2011.
URI: https://hdl.handle.net/11499/5939
https://doi.org/10.1177/1076029610364518
ISSN: 1076-0296
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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