Relationship of admission mean platelet volume with no-reflow in acute myocardial infarction treated with fibrinolysis

Abstract

Platelets play a central role in the pathogenesis of acute coronary syndromes. Mean platelet volume (MPV) is a controversial issue in platelet reactivity, the extent of coronary artery disease, and response to reperfusion therapy. Thus, we sought to determine the relationship of admission MPV and no-reflow in patients with acute STsegment elevation myocardial infarction (STEMI) treated with fibrinolysis. 164 patients (143 male, 21 female) who had presented with STEMI treated with fibrinolysis and had undergone coronary angiography, were included in our study. Blood samples for MPV estimation were obtained on admission. All angiograms were assessed with respect to TIMI flow scale in infarct-related artery. Patients were divided in two groups: group 1 with reflow (TIMI=3, n = 42) and group 2 with no-reflow (TIMI<3, n = 122). Both univariate and multivariate analyses were performed on clinical and laboratory factors with relation to angiographic reperfusion. All characteristics were similar between the two groups. MPV was not associated with no-reflow (p=0.504). Multivariate analysis determined that RCA as an IRA was independent predictor of angiographic reperfusion. No-reflow phenomenon was observed significantly fewer when RCA was an IRA (odds ratio 2.6, 95% confidence interval 1.2 to 5.3, p=0.009). Our study showed that MPV is not related to angiographic reperfusion in patients with STEMI treated with fibrinolysis.