Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/6023
Title: A relationship between CRP, adiponectin and Gensini score in the patients with coronary artery disease
Other Titles: Koroner arter hastalarında CRP, adiponektin ve Gensini skoru arasındaki ilişki
Authors: Dursunoglu, Dursun
Göksoy, Hidayet
Öztürk, Mehmed
Rota, Simin
Keywords: Adiponectin
Angiography
C-reactive protein
Coronary artery disease
Gensini score
Logistic regression analysis
adiponectin
C reactive protein
adult
angiocardiography
article
controlled study
coronary artery disease
disease association
disease severity
down regulation
female
human
major clinical study
male
protein blood level
scoring system
upregulation
aged
blood
case control study
cross-sectional study
hospitalization
middle aged
radiography
statistical model
Adult
Aged
C-Reactive Protein
Case-Control Studies
Coronary Angiography
Coronary Artery Disease
Cross-Sectional Studies
Female
Humans
Logistic Models
Male
Middle Aged
Severity of Illness Index
Abstract: Objective: We aimed to evaluate serum adiponectin and C-reactive protein (CRP) levels in the different groups of patients with angiographically defined coronary artery disease (CAD). Methods: Overall 100 patients (80 males, 20 females) with CAD (? 50% stenosis) and 45 controls (25 males, 20 females) with normal coronary arteries were included in this cross-sectional observational study. Gensini score was used for evaluation of the severity of coronary lesions on the angiogram. A relationship between Gensini score and serum CRP and adiponectin levels was evaluated by a logistic regression analysis. Results: Mean age of the patients (60.5±10.2 years) was significantly higher than of the controls (55.6±10.4 years, p=0.01). While serum adiponectin levels in CAD patients (2.1±1.2 µmg/dl) were significantly lower than in the controls (3.3±1.8 µmg/dl, p=0.01); serum CRP levels of the patients (2.8±1.5 mg/dl) were significantly higher than of the controls (0.9±0.4 mg/dl). Serum adiponectin and CRP levels were not significantly different between the CAD subgroups (p>0.05). Gensini score was related with serum CRP (odds ratio: 0.98, 95% CI: 1.05-1.35, p=0.01) and adiponectin levels (odds ratio: 1.15, 95% CI: 1.10-1.25, p=0.01) by a logistic regression analysis. Conclusion: While serum CRP levels are increased in CAD patients comparing with the controls; serum adiponectin levels are decreased significantly. Serum CRP and adiponectin levels are related to coronary lesions severity on the angiogram. © 2011 by AVES Yayi{dotless}nci{dotless}li{dotless}k Ltd.
URI: https://hdl.handle.net/11499/6023
https://doi.org/10.5152/akd.2011.052
ISSN: 1302-8723
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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