Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/60288
Title: Acute Disseminated Encephalomyelitis in Children and Adolescents: a Multicenter Retrospective Study of Relapse and Outcome
Authors: Kanmaz, S.
Yılmaz, S.
Dündar, N.O.
Aksoy, A.
Canpolat, M.
Per, H.
Anlar, B.
Keywords: Autoimmune
Encephalitis
Neuroimmunology
Outcome
Publisher: SAGE Publications Inc.
Abstract: Objectives: To evaluate the demographic, clinical, laboratory, and prognostic data of children with acute disseminated encephalomyelitis with respect to anti-myelin oligodendrocyte glycoprotein (MOG) antibody status. Methods: Acute disseminated encephalomyelitis patients (n = 245) from 24 centers followed up between 2010 and 2022 were evaluated retrospectively. The short- and long-term outcome characteristics (disease severity and course, clinical relapse, and recovery rates) were assessed. Incomplete clinical recovery was defined as modified Rankin Score ≥1 or the presence of epilepsy. Univariant and multivariant analysis were performed for outcome characteristics. Results: The mean age at diagnosis was 6.3 ± 3.8 (0.5-17.7) years and the median follow-up was 22 (3-132) months. The outcome characteristics were evaluated in 180 of 245 patients (73.4%) with at least 12 months’ follow-up. Twenty-three patients (12.6%) relapsed. The multivariable logistic regression analysis revealed the following clinical parameters as predictors of relapse: sex, visual impairment, and ataxia at initial presentation. Incomplete clinical recovery (n = 42/180, 23.3%) was associated with the presence of seizures on admission and the need for an intensive care unit. Anti-MOG antibody positivity was not associated with an increased risk of relapse (25% vs 13.1%, P =.164) or incomplete clinical recovery (P =.511). Conclusion: The nationwide cohort presented further supports the typically monophasic nature of acute disseminated encephalomyelitis, and a high rate of complete recovery. The presence of certain symptoms in the acute period may assist the clinician in estimating the outcome. © The Author(s) 2025.
URI: https://doi.org/10.1177/08830738251334219
https://hdl.handle.net/11499/60288
ISSN: 8830-738
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

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