The Effect of GLUT-1-XbaI G>T and HaeIII T>C Polymorphisms on 18F-FDG Uptake Rates

Abstract

Objectives: To investigate the effects of glut polymorphisms on 18Fluorine-fluorodeoxyglucose (F-18-FDG) uptake rates. Methods: The F-18-FDG positron emission tomography/computed tomography images and mass lesion metabolism standard uptake value maximum (SUVmax) results of the patients were evaluated. Glucose transporter protein-1 (GLUT-1)-XbaI G>T (rs2754218) and HaeIII T>C (rs1385129) polymorphisms and their effects on F-18-FDG uptake rates were investigated using DNA obtained from peripheral blood. Results: When the Xbal G>T genotype distribution of the patients was examined, the Xbal G/G genotype was found to be 87%, the Xbal G/T genotype 12%. The XbaI T/T phenotype was detected in only one patient (1%). In the HaeIII T>C genotype distribution, the HaeIII C/C genotype was found as 54%, the HaeIII T/C genotype as 31%, and the HaeIII T/T genotype as 15%. When the Xbal and HaeIII genotypes were examined together, the number of polymorphic genotypes was significantly higher in the lung and bronchial tumor groups compared to other cancer types. Conclusion: The presence of polymorphism in at least one of the two gene regions, in the lung-bronchial tumor group and the high SUVmax value in this patient group, may indicate a change in the involvement rates.