Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/6051
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dc.contributor.authorUrhan-Kucuk, M.-
dc.contributor.authorErdal, M.E.-
dc.contributor.authorOzen, M.E.-
dc.contributor.authorKul, S.-
dc.contributor.authorHerken, Hasan-
dc.date.accessioned2019-08-16T12:03:54Z
dc.date.available2019-08-16T12:03:54Z
dc.date.issued2011-
dc.identifier.issn0301-4851-
dc.identifier.urihttps://hdl.handle.net/11499/6051-
dc.identifier.urihttps://doi.org/10.1007/s11033-010-0396-4-
dc.description.abstractSchizophrenia is one of the neuropathological disorders, which are associated with dopamine and its receptors. In recent years, it has been shown that mRNA of D3, D4 and D5 dopamine receptor (DRD3, DRD4, DRD5) subtypes is expressed in human peripheral blood lymphocytes (PBL). A total 55 schizophrenic patients and 51 healthy subjects were included in the study to investigate the levels of DRD3 mRNA in PBL of schizophrenic patients and whether DRD3 mRNA level in PBL can serve as peripheral marker for schizophrenia. RNA was isolated from lymphocytes of both groups and reverse transcriptase polymerase chain reaction (RT-PCR) was performed for DRD3 mRNA. We found a significant difference in PBL DRD3 mRNA levels among schizophrenia subtypes (P = 0.030) while no difference was detected between control subjects and schizophrenics. We concluded that the levels of DRD3 mRNA can help understanding and severity of clinical manifestations in schizophrenia. © Springer Science+Business Media B.V. 2010.en_US
dc.language.isoenen_US
dc.relation.ispartofMolecular Biology Reportsen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDRD3 mRNAen_US
dc.subjectPBLen_US
dc.subjectRT-PCRen_US
dc.subjectSchizophreniaen_US
dc.subjectdopamine 3 receptoren_US
dc.subjectmessenger RNAen_US
dc.subjectdiagnostic agenten_US
dc.subjectprimer DNAen_US
dc.subjectadulten_US
dc.subjectarticleen_US
dc.subjectcontrolled studyen_US
dc.subjectdisease markeren_US
dc.subjectdisease severityen_US
dc.subjectfemaleen_US
dc.subjecthumanen_US
dc.subjecthuman cellen_US
dc.subjectlymphocyteen_US
dc.subjectmajor clinical studyen_US
dc.subjectmaleen_US
dc.subjectreverse transcription polymerase chain reactionen_US
dc.subjectRNA analysisen_US
dc.subjectRNA isolationen_US
dc.subjectschizophreniaen_US
dc.subjectclassificationen_US
dc.subjectgeneticsen_US
dc.subjectmetabolismen_US
dc.subjectnonparametric testen_US
dc.subjectDNA Primersen_US
dc.subjectHumansen_US
dc.subjectLymphocytesen_US
dc.subjectReceptors, Dopamine D3en_US
dc.subjectReverse Transcriptase Polymerase Chain Reactionen_US
dc.subjectRNA, Messengeren_US
dc.subjectStatistics, Nonparametricen_US
dc.titleIs the dopamine D3 receptor mRNA on blood lymphocytes help to for identification and subtyping of schizophrenia?en_US
dc.typeArticleen_US
dc.identifier.volume38en_US
dc.identifier.issue4en_US
dc.identifier.startpage2569
dc.identifier.startpage2569en_US
dc.identifier.endpage2572en_US
dc.identifier.doi10.1007/s11033-010-0396-4-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.pmid21110120en_US
dc.identifier.scopus2-s2.0-79960956501en_US
dc.identifier.wosWOS:000289257100044en_US
dc.identifier.scopusqualityQ2-
dc.ownerPamukkale University-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairetypeArticle-
crisitem.author.dept14.02. Internal Medicine-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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