Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/6110
Title: Congenital arterial thrombosis in newborn: A case report
Authors: Özdemir, Özmert M.A.
Kılıç, İlknur
Küçüktaşçı, Kazım
Gürses, Dolunay
Karaca, Abdullah
Oto, Murat
Çetin, Gökhan Ozan
Keywords: Congenital arterial thrombosis
Methylene-tetrahydrofolate reductase gene polymorphsim
acetylsalicylic acid
cyanocobalamin
folic acid
heparin
pyridoxine
arm amputation
artery thrombosis
article
brachial artery
capillary flow
case report
congenital brachial arterial thrombosis
congenital disorder
congenital radial arterial thrombosis
congenital ulnar arterial thrombosis
gene
genetic association
genetic polymorphism
heterozygosity
human
methylene tetrahydrofolate reductase gene
newborn
radial artery
ulnar artery
Publisher: Galenos Publishing House
Abstract: Neonatal thrombosis is a serious event that can cause mortality or severe morbidity. Although catheters are the most common cause of neonatal thrombosis, spontaneous events can also occur. Arterial thrombosis is very rare and accounts for approximately half of all thrombotic events in neonates. Genetic prothrombotic risk factors may affect the occurence of neonatal thrombosis. In this report, a case of left brachial, radial, and ulnar arterial thrombosis associated with methylene-tetrahydrofolate reductase (MTHFR) gene C677T and A1298C polymorphism heterozygosity is presented. Plasma homocysteine level and other prothrombotic components were normal. Standard heparin, aspirin, vitamin B12, B6 and folic acid were initiated for treatment. However, the left arm of the patient was amputated at the shoulder because its capillary stream could not be observed. We suggest that MTHFR gene C677T and A1298C polymorphism heterozygosity might be investigated in neonates with congenital arterial thrombosis in spite of normal serum homocysteine levels. © Trakya University Faculty of Medicine.
URI: https://hdl.handle.net/11499/6110
https://doi.org/10.5174/tutfd.2009.03070.1
ISSN: 2146-3123
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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