Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/6128
Title: Preventive effects of vitamin e against oxidative damage in aged diabetic rat bladders
Authors: Aybek, Hülya
Aybek, Zafer
Abban, G.
Rota, S.
Keywords: free radical
glutathione
malonaldehyde
tocopherol
aging
animal experiment
animal model
animal tissue
article
bladder
bladder dysfunction
blood level
controlled study
diabetes mellitus
electron microscopy
histology
histopathology
male
nonhuman
oxidative stress
priority journal
rat
streptozocin diabetes
tissue degeneration
vitamin supplementation
Publisher: Elsevier Inc.
Abstract: Objectives To examine the effects of aging and/or diabetes mellitus on oxidative stress and the protective effect of vitamin E in the bladder. It was proposed that the balance between oxidant and antioxidant species is important regarding the aging process and prevention of diabetic complications. Methods Young and aged rats were randomly allotted into six experimental groups: aged control, aged diabetic, aged diabetic and vitamin Etreated, young control, young diabetic, young diabetic and vitamin Etreated. Diabetes was induced by streptozotocin. Vitamin E was administered to the treated groups. Malondialdehyde and reduced glutathione levels were measured in all rat bladders, and histological changes were examined by electron microscopy. Results We found increased malondialdehyde and decreased glutathione levels in the young and aged diabetic groups compared with the nondiabetic control groups. Elevated malondialdehyde and reduced glutathione levels were observed in the aged compared with the young control groups. There were no significant differences in the malondialdehyde and glutathione levels between young and aged diabetic vitamin Etreated groups compared with the related control groups. Degeneration was greatest in the aged diabetic group. The protective effects of vitamin E were seen in young and aged diabetic groups, especially in the young diabetic group. Conclusions Our results suggest that vitamin E supplementation prevents free radical damage in bladders of young and aged diabetic rats. © 2011 Elsevier Inc.
URI: https://hdl.handle.net/11499/6128
https://doi.org/10.1016/j.urology.2010.08.015
ISSN: 0090-4295
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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