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https://hdl.handle.net/11499/6129
Title: | Angiotensin converting enzyme I/D, angiotensinogen M235T and AT1-R A/C1166 gene polymorphisms in patients with acromegaly | Authors: | Turgut, Sebahat Akın, F. Akcılar, R. Ayada, C. Turgut, Günfer |
Keywords: | Acromegaly Angiotensin converting enzyme Angiotensinogen AT1-receptor Polymorphism angiotensin 1 receptor angiotensinogen dipeptidyl carboxypeptidase high density lipoprotein cholesterol insulin low density lipoprotein cholesterol somatomedin C triacylglycerol acromegaly adult article body mass cholesterol blood level clinical article controlled study diastolic blood pressure female gene frequency genetic association genetic polymorphism genotype glucose blood level growth hormone blood level homozygosity human hypertension insulin blood level insulin resistance male protein denaturation systolic blood pressure triacylglycerol blood level |
Publisher: | Kluwer Academic Publishers | Abstract: | Acromegaly is associated with increased morbidity and mortality related to cardiovascular disease. Hypertension is one of the most common cardiovascular risk factors in acromegalic patients. The aim of this study was to investigate association between the frequencies of angiotensin converting enzyme (ACE) I/D, angiotensinogen (AGT) M235T and the angiotensin II type 1 receptor (AT1-R) A/C1166 gene polymorphisms and some clinical parameters of acromegalic patients. Total of 33 acromegalic patients and 63 controls were enrolled to study. We determined the ACE I/D, AGT M235T and AT1-R A/C1166 gene polymorphisms. Serum insulin, glucose, triglyceride, HDL-cholesterol, LDL-cholesterol, growth hormone and Insulin-like growth factor I (IGF-I) levels of subjects were analyzed. The frequencies of ACE and M235T AGT genotype were not significantly different between control and patients. The distribution of AT1R A/C1166 genotypes was significantly different between patients and control subjects (P = 0.016). None of the three ACE genotypes, DD, ID and II displayed significant difference in acromegalic patients. A significant difference in systolic blood pressure and the serum IGF-I levels among the three AGT genotype, MM, MT and TT genotypes was found in patient group. Individuals with MT genotypes had significantly higher serum IGF-I levels and systolic blood pressure than MM and TT genotype subjects, P < 0.05. In addition, serum triglyceride and HDL levels differed significantly between MM and MT genotypes, P < 0.05. However, systolic blood pressure of patients with CC genotypes was found to be significantly higher than AA genotypes individuals in acromegaly group, P < 0.05. It can be said that the angiotensinojen MT and AT1R CC1166 genotype carriers may have more risk than other genotypes in the development of hypertension in acromegaly. © 2010 Springer Science+Business Media B.V. | URI: | https://hdl.handle.net/11499/6129 https://doi.org/10.1007/s11033-010-0142-y |
ISSN: | 0301-4851 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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