Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/6142
Title: Hippocampal neuron number loss in rats exposed to ingested sulfite
Authors: Akdoğan, Ilgaz
Kocamaz, Erdoğan
Küçükatay, Vural
Yonguç, Nilüfer G.
Özdemir, Mehmet Bülent
Murk, W.
Keywords: hippocampus
rat
Sulfite
sulfite oxidase
the optical fractionator
sulfite
animal cell
animal experiment
animal tissue
apoptosis
article
cell count
cell loss
controlled study
hippocampal CA1 region
hippocampal CA2 region
hippocampal CA3 region
male
nonhuman
pyramidal nerve cell
stereology
Administration, Oral
Animals
CA1 Region, Hippocampal
CA2 Region, Hippocampal
CA3 Region, Hippocampal
Cell Count
Cell Death
Food Preservatives
Hippocampus
Male
Microscopy, Video
Neurons
Neurotoxicity Syndromes
Preservatives, Pharmaceutical
Pyramidal Cells
Rats
Rats, Wistar
Sulfites
Animalia
Rattus
Abstract: Sulfite, which is continuously formed in the body during metabolism of sulfur-containing amino acids, is commonly used in preservatives. It has been shown that there are toxic effects of sulfite on many cellular components. The aim of this study was to investigate the possible toxic effects of sulfite on pyramidal neurons by counting cell numbers in CA1 and CA2-CA3 subdivisions of the rat hippocampus. For this purpose, male albino rats were divided into a control group and a sulfite group (25 mg/kg). Sulfite was administered to the animals via drinking water for 8 weeks. At the end of the experimental period, brains were removed and neurons were estimated in total and in a known fraction of CA1 and CA2-CA3 subdivisions of the left hippocampus by using the optical fractionator method—a stereological method. Results showed that sulfite treatment caused a significant decrease in the total number of pyramidal neurons in three subdivisions of the hippocampus (CA1 and CA2-CA3) in the sulfite group compared with the control group (p < 0.05, Mann Whitney U test). It was concluded that exogenous administration of sulfite causes loss of pyramidal neurons in CA1 and CA2-CA3 subdivisions of the rat hippocampus. © 2011, SAGE Publications. All rights reserved.
URI: https://hdl.handle.net/11499/6142
https://doi.org/10.1177/0748233710397418
ISSN: 0748-2337
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Show full item record



CORE Recommender

SCOPUSTM   
Citations

17
checked on Jun 1, 2024

WEB OF SCIENCETM
Citations

14
checked on Jun 7, 2024

Page view(s)

54
checked on May 27, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.