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https://hdl.handle.net/11499/6176
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DC Field | Value | Language |
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dc.contributor.author | Basoglu, C. | - |
dc.contributor.author | Oner, O. | - |
dc.contributor.author | Ates, A. | - |
dc.contributor.author | Algul, A. | - |
dc.contributor.author | Bez, Y. | - |
dc.contributor.author | Cetin, M. | - |
dc.contributor.author | Herken, Hasan | - |
dc.date.accessioned | 2019-08-16T12:04:46Z | |
dc.date.available | 2019-08-16T12:04:46Z | |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0706-7437 | - |
dc.identifier.uri | https://hdl.handle.net/11499/6176 | - |
dc.identifier.uri | https://doi.org/10.1177/070674371105600605 | - |
dc.description.abstract | Objective: The molecular genetic of personality disorders has been investigated in several studies; however, the association of antisocial behaviours with synaptosomal-associated protein 25 (SNAP25) gene polymorphisms has not. This association is of interest as SNAP25 gene polymorphism has been associated with attention-deficit hyperactivity disorder and personality. Methods: We compared the distribution of DdeI and MnlI polymorphisms in 91 young male offenders and in 38 sex-matched healthy control subjects. We also investigated the association of SNAP25 gene polymorphisms with severity of psychopathy and with temperament traits: novelty seeking, harm avoidance, and reward dependence. Results: The MnlI T/T and DdeI T/T genotypes were more frequently present in male subjects with antisocial personality disorder (APD) than in sex-matched healthy control subjects. The association was stronger when the frequency of both DdeI and MnlI T/T were taken into account. In the APD group, the genotype was not significantly associated with the Psychopathy Checklist - Revised scores, measuring the severity of psychopathy. However, the APD subjects with the MnlI T/T genotype had higher novelty seeking scores; whereas, subjects with the DdeI T/T genotype had lower reward dependence scores. Again, the association between genotype and novelty seeking was stronger when both DdeI and MnlI genotypes were taken into account. Conclusion: DdeI and MnlI T/T genotypes may be a risk factor for antisocial behaviours. The association of the SNAP25 DdeI T/T and MnlI T/T genotypes with lower reward dependence and higher novelty seeking suggested that SNAP25 genotype might influence other personality disorders, as well. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Canadian Psychiatric Association | en_US |
dc.relation.ispartof | Canadian Journal of Psychiatry | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Antisocial personality disorder | en_US |
dc.subject | Gene polymorphism | en_US |
dc.subject | Personality disorder | en_US |
dc.subject | Psychopathy | en_US |
dc.subject | Synaptosomal-associated protein 25 gene | en_US |
dc.subject | Temperament | en_US |
dc.subject | synaptosomal associated protein 25 | en_US |
dc.subject | adult | en_US |
dc.subject | antisocial behavior | en_US |
dc.subject | article | en_US |
dc.subject | controlled study | en_US |
dc.subject | Diagnostic and Statistical Manual of Mental Disorders | en_US |
dc.subject | disease severity | en_US |
dc.subject | DNA polymorphism | en_US |
dc.subject | gene frequency | en_US |
dc.subject | genetic association | en_US |
dc.subject | genotype | en_US |
dc.subject | harm reduction | en_US |
dc.subject | help seeking behavior | en_US |
dc.subject | human | en_US |
dc.subject | major clinical study | en_US |
dc.subject | male | en_US |
dc.subject | nucleotide sequence | en_US |
dc.subject | offender | en_US |
dc.subject | psychopathy | en_US |
dc.subject | Psychopathy Checklist Revised Score | en_US |
dc.subject | reward | en_US |
dc.subject | scoring system | en_US |
dc.subject | structured interview | en_US |
dc.subject | temperament | en_US |
dc.title | Synaptosomal-associated protein 25 gene polymorphisms and antisocial personality disorder: Association with temperament and psychopathy | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 56 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.startpage | 341 | |
dc.identifier.startpage | 341 | en_US |
dc.identifier.endpage | 347 | en_US |
dc.identifier.doi | 10.1177/070674371105600605 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.pmid | 21756448 | en_US |
dc.identifier.scopus | 2-s2.0-79960441556 | en_US |
dc.identifier.wos | WOS:000291765700005 | en_US |
dc.identifier.scopusquality | Q1 | - |
dc.owner | Pamukkale University | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.openairetype | Article | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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070674371105600605.pdf | 269.6 kB | Adobe PDF | View/Open |
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