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Title: | The volume fraction of brain ventricles to total brain volume: A computed tomography stereological study | Authors: | Akdoğan, Ilgaz Kıroğlu, Yılmaz Onur, Şule Karabulut, Nevzat |
Keywords: | Brain ventricles Brain volume Cavalieri method Stereology Volume fraction adolescent adult aging Alzheimer disease article brain brain ventricle brain ventriculography computer assisted tomography female histology human hydrocephalus male middle aged organ size pathology radiography schizophrenia sexual development Adolescent Adult Aging Alzheimer Disease Brain Cerebral Ventricles Cerebral Ventriculography Female Humans Hydrocephalus Male Middle Aged Organ Size Schizophrenia Sex Characteristics Tomography, X-Ray Computed Young Adult |
Abstract: | This study has been designed to estimate the volume fraction of the brain ventricles volume to total brain volume and to correlate them with gender and age in normal subjects. Cranial computed tomography (CT) images of 80 normally evaluated subjects (five female and five male for each decade) were selected from 1,073 CT examinations. The volumes of total brain, cerebral aqueduct, fourth, third, and lateral ventricles and their ratios were estimated using the Cavalieri method and volume fraction-stereological methods. The ratio of total brain ventricle volume to total brain volume was comparable between the two genders (p > 0.05, independent t test). Mean volume fraction of total ventricle volume to total brain volume was found to be 1.21% in the first and 3.37% in the last decades. Mean volume fraction was found to increase significantly with age (p < 0.01, r = 0.630, Pearson). In conclusion, the mean percentage of total ventricle volume within the total brain volume was found to be 2%. We demonstrated the volume fraction of total ventricle to total brain in normal subjects. Total ventricle volume to total brain volume fractions can be important tools in determining ventricle volumes, which denote variability in some diseases (Alzheimer, schizophrenia, neurodegenerative disorders, etc.) and can be estimated by stereological methods. Copyright © 2010 Via Medica. | URI: | https://hdl.handle.net/11499/6194 | ISSN: | 0015-5659 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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