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https://hdl.handle.net/11499/6284
Title: | Comparison of antimicrobial agents as therapy for experimental endocarditis | Authors: | Sacar, M. Sacar, S. Cevahir, N.ural Önem, Gökhan Teke, Z. Asan, A. Turgut, Hüseyin |
Keywords: | Animal Anti-bacterial agents/pharmacology/therapeutic use Disease models Drug resistance, microbial Endocarditis, bacterial/microbiology/drug therapy Linezolid Methicillin resistance Microbial sensitivity tests Rodents Staphylococcal infections/epidemiology Staphylococcus aureus/drug effects Teicoplanin Vancomycin antiinfective agent dalfopristin dalfopristin plus quinupristin linezolid polyethylene teicoplanin vancomycin animal experiment animal model antibiotic therapy article bacterial count bacterial endocarditis bacterium culture colony forming unit controlled study drug efficacy experimental infection experimental model experimental rat heart catheterization heart left ventricle inoculation loading drug dose male methicillin resistant Staphylococcus aureus nonhuman rat Acetamides Animals Anti-Infective Agents Aortic Valve Colony Count, Microbial Disease Models, Animal Endocarditis, Bacterial Infusions, Intravenous Injections, Intravenous Male Methicillin-Resistant Staphylococcus aureus Oxazolidinones Rats Rats, Wistar Time Factors Virginiamycin |
Abstract: | We used an experimental rat model to compare the therapeutic efficacy of teicoplanin, linezolid, and quinupristin/dalfopristin with that of vancomycin as standard therapy for infective endocarditis. Aortic endocarditis was induced in rats by insertion of a polyethylene catheter into the left ventricle, followed by intravenous inoculation of 106 colony-forming units of methicillin-resistant Staphylococcus aureus 24 hours later. Forty-eight hours after bacterial challenge, intravenous antibiotic therapies were initiated. There were 6 groups of 8 rats each: uninfected control; infected, untreated control; vancomycin-treated (40 mg/kg twice daily); teicoplanin-treated (20 mg/kg twice daily after a loading dose of 40 mg/kg); linezolid-treated (75 mg/kg 3 times daily for 1 day, then 75 mg/kg twice daily); and quinupristin/dalfopristintreated (30 mg/kg twice daily and an additional 10 mg/kg dalfopristin infusion over 6 to 12 hr daily). At the end of therapy, the aortic valve vegetations in the drug-treated rats were evaluated microbiologically. Compared with the infected, untreated group, all drug-treated groups had significantly reduced bacterial titers in the vegetations. Vancomycin, teicoplanin, and quinupristin/dalfopristin all effectively reduced the quantitative bacterial cultures of aortic valve vegetations. In addition, there was no significant difference in the comparative efficacy of teicoplanin, linezolid, and quinupristin/dalfopristin. Vancomycin significantly reduced bacterial counts in comparison with linezolid, which was nonetheless also effective. Our experimental model showed that each of the investigated antimicrobial agents was effective in the treatment of infective endocarditis. © 2010 by the Texas Heart® Institute, Houston. | URI: | https://hdl.handle.net/11499/6284 | ISSN: | 0730-2347 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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