Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/6284
Title: Comparison of antimicrobial agents as therapy for experimental endocarditis
Authors: Sacar, M.
Sacar, S.
Cevahir, N.ural
Önem, Gökhan
Teke, Z.
Asan, A.
Turgut, Hüseyin
Keywords: Animal
Anti-bacterial agents/pharmacology/therapeutic use
Disease models
Drug resistance, microbial
Endocarditis, bacterial/microbiology/drug therapy
Linezolid
Methicillin resistance
Microbial sensitivity tests
Rodents
Staphylococcal infections/epidemiology
Staphylococcus aureus/drug effects
Teicoplanin
Vancomycin
antiinfective agent
dalfopristin
dalfopristin plus quinupristin
linezolid
polyethylene
teicoplanin
vancomycin
animal experiment
animal model
antibiotic therapy
article
bacterial count
bacterial endocarditis
bacterium culture
colony forming unit
controlled study
drug efficacy
experimental infection
experimental model
experimental rat
heart catheterization
heart left ventricle
inoculation
loading drug dose
male
methicillin resistant Staphylococcus aureus
nonhuman
rat
Acetamides
Animals
Anti-Infective Agents
Aortic Valve
Colony Count, Microbial
Disease Models, Animal
Endocarditis, Bacterial
Infusions, Intravenous
Injections, Intravenous
Male
Methicillin-Resistant Staphylococcus aureus
Oxazolidinones
Rats
Rats, Wistar
Time Factors
Virginiamycin
Abstract: We used an experimental rat model to compare the therapeutic efficacy of teicoplanin, linezolid, and quinupristin/dalfopristin with that of vancomycin as standard therapy for infective endocarditis. Aortic endocarditis was induced in rats by insertion of a polyethylene catheter into the left ventricle, followed by intravenous inoculation of 106 colony-forming units of methicillin-resistant Staphylococcus aureus 24 hours later. Forty-eight hours after bacterial challenge, intravenous antibiotic therapies were initiated. There were 6 groups of 8 rats each: uninfected control; infected, untreated control; vancomycin-treated (40 mg/kg twice daily); teicoplanin-treated (20 mg/kg twice daily after a loading dose of 40 mg/kg); linezolid-treated (75 mg/kg 3 times daily for 1 day, then 75 mg/kg twice daily); and quinupristin/dalfopristintreated (30 mg/kg twice daily and an additional 10 mg/kg dalfopristin infusion over 6 to 12 hr daily). At the end of therapy, the aortic valve vegetations in the drug-treated rats were evaluated microbiologically. Compared with the infected, untreated group, all drug-treated groups had significantly reduced bacterial titers in the vegetations. Vancomycin, teicoplanin, and quinupristin/dalfopristin all effectively reduced the quantitative bacterial cultures of aortic valve vegetations. In addition, there was no significant difference in the comparative efficacy of teicoplanin, linezolid, and quinupristin/dalfopristin. Vancomycin significantly reduced bacterial counts in comparison with linezolid, which was nonetheless also effective. Our experimental model showed that each of the investigated antimicrobial agents was effective in the treatment of infective endocarditis. © 2010 by the Texas Heart® Institute, Houston.
URI: https://hdl.handle.net/11499/6284
ISSN: 0730-2347
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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