Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/6304
Title: A sex-related genetic difference in bipolar disorder: Tryptophan hydroxylase 1 gene 218 A>C polymorphism
Authors: Özen, M.E.
Yumru, M.
Erdal, M.E.
Herken, Hasan
Savaş, H.A.
Keywords: Bipolar disorder
Gender
Genetic
Tryptophan hydroxylase
serotonin
tryptophan hydroxylase
tryptophan hydroxylase 1
unclassified drug
adult
age distribution
aged
allele
article
bipolar disorder
controlled study
female
gene frequency
gene linkage group
gene locus
genetic difference
genetic polymorphism
genetic susceptibility
genetic variability
genotype
human
major clinical study
male
serotonin brain level
sex difference
tryptophan brain level
Turkey (republic)
Abstract: Objective: Considering the suggested association of tryptophan hydroxylase gene 1 (TPH1) polymorphism with some psychiatric disorders and studies concerning serotonin's effect on TPH 1 gene, brain and the neurotransmitter monoamines, as well as the studies performed on the serotonin levels in cerebrospinal fluid of bipolar patients, we aimed to investigate the frequencies and distribution of TPH 1 gene 218 A>C (rs1800532) polymorphism; A/A, A/C and C/C genotypes in bipolar patients and healthy control subjects for the first time in Turkish population (1-2). Methods: One hundred and sixteen adult patients who applied to the Mood Disorders Unit of Psychiatry Department, Medical School of Gaziantep University, and diagnosed with bipolar disorder (BD) according to DSM-IV diagnostic criteria were included in the study. One hundred and fifty healthy volunteers, a hospital staff at Gaziantep University, were involved as the control group. Results: In female patients, the frequency of A/A genotype was found to be higher than in the females in the control group. No significant difference was detected between patient and control groups in terms of age and gender distribution. The distribution of A/A, A/C and C/C genotypes were similar in patient and control groups. Conclusion: The distribution of TPH1 gene 218 A>C polymorphism was found to be significantly different between female patients and females in the control group. This result can be explicated as being one of the possible reasons for different course of bipolar disorder in male and female patients. © Archives of Neuropsychiatry.
URI: https://hdl.handle.net/11499/6304
https://doi.org/10.4274/npa.5326
ISSN: 1300-0667
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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