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https://hdl.handle.net/11499/6335
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DC Field | Value | Language |
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dc.contributor.author | Işklan, M. | - |
dc.contributor.author | Asmafiliz, N. | - |
dc.contributor.author | Özalp, E.E. | - |
dc.contributor.author | Ïlter, E.E. | - |
dc.contributor.author | Kiliç, Z. | - |
dc.contributor.author | Çoşut, B. | - |
dc.contributor.author | Yeşilot, S. | - |
dc.date.accessioned | 2019-08-16T12:06:03Z | |
dc.date.available | 2019-08-16T12:06:03Z | |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0020-1669 | - |
dc.identifier.uri | https://hdl.handle.net/11499/6335 | - |
dc.identifier.uri | https://doi.org/10.1021/ic100781v | - |
dc.description.abstract | The reactions of hexachlorocyclotriphosphazatriene, N 3P 3Cl 6, with N/O-donor-type N-alkyl (or aryl)-o- hydroxybenzylamines (1a-1e) produce mono- (2a-2e), di- (3a-3d), and tri- (4a and 4b) spirocyclic phosphazenes. The tetrapyrrolidino monospirocyclic phosphazenes (2f-2i) are prepared from the reactions of partly substituted compounds (2a-2d) with excess pyrrolidine. The dispirodipyrrolidinophosphazenes (3e-3h) and trispirophosphazenes (3i-3k) are obtained from the reactions of trans-dispirophosphazenes with excess pyrrolidine and sodium (3-amino-1-propanoxide), respectively. Compounds 3a-3d have cis and trans geometric isomers. Only the trans isomers of these compounds are isolated. Compounds 3a-3h have two stereogenic P atoms. They are expected to be in cis (meso) and trans (racemic) geometric isomers. In the trans trispiro compounds (3i-3k), there are three stereogenic P atoms. They are expected to be in racemic mixtures. The stereogenic properties of 3a-3k are confirmed by 31P NMR spectroscopy upon the addition of the chiral solvating agent; (S)-(+)-2,2,2-trifluoro-1-(9'-anthryl)ethanol. The molecular structures of 3i-3k, 4a, and 4b look similar to a propeller, where the chemical environment of one P atom is different from that of others. Additionally, 4a and 4b are also expected to exist as cis-trans-trans and cis-cis-cis geometric isomers, but both of them are found to be in cis-trans-trans geometries. The solid-state structures of 2a, 2e, 2f, 3e, and 3f are determined by X-ray crystallography. The compounds 2f-2i, 3e-3i, and 3k are screened for antibacterial activity against Gram-positive and Gram-negative bacteria and for antifungal activity against yeast strains. These compounds (except 3f) have shown a strong affinity against most of the bacteria. Minimum inhibitory concentrations (MIC) are determined for 2f-2i, 3e-3i, and 3k. DNA binding and the nature of interaction with pUC18 plasmid DNA are studied. The compounds 2f-2i, 3e-3i, and 3k induce changes on the DNA mobility. The prevention of BamHI and HindIII digestion (except 2g) with compounds indicates that the compounds bind with nucleotides in DNA. © 2010 American Chemical Society. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Inorganic Chemistry | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | DNA | en_US |
dc.subject | nitrogen | en_US |
dc.subject | phosphorus | en_US |
dc.subject | restriction endonuclease | en_US |
dc.subject | solvent | en_US |
dc.subject | spiro compound | en_US |
dc.subject | article | en_US |
dc.subject | bacterium | en_US |
dc.subject | chemistry | en_US |
dc.subject | drug effect | en_US |
dc.subject | fungus | en_US |
dc.subject | infrared spectroscopy | en_US |
dc.subject | mass spectrometry | en_US |
dc.subject | metabolism | en_US |
dc.subject | nuclear magnetic resonance spectroscopy | en_US |
dc.subject | quantum theory | en_US |
dc.subject | stereoisomerism | en_US |
dc.subject | synthesis | en_US |
dc.subject | X ray crystallography | en_US |
dc.subject | Bacteria | en_US |
dc.subject | Crystallography, X-Ray | en_US |
dc.subject | DNA Restriction Enzymes | en_US |
dc.subject | Fungi | en_US |
dc.subject | Magnetic Resonance Spectroscopy | en_US |
dc.subject | Mass Spectrometry | en_US |
dc.subject | Nitrogen | en_US |
dc.subject | Phosphorus | en_US |
dc.subject | Quantum Theory | en_US |
dc.subject | Solvents | en_US |
dc.subject | Spectroscopy, Fourier Transform Infrared | en_US |
dc.subject | Spiro Compounds | en_US |
dc.subject | Stereoisomerism | en_US |
dc.title | Phosphorus-nitrogen compounds. 21. Syntheses, structural investigations, biological activities, and DNA interactions of new N/O spirocyclic phosphazene derivatives. the NMR behaviors of chiral phosphazenes with stereogenic centers upon the addition of chiral solvating agents | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 49 | en_US |
dc.identifier.issue | 15 | en_US |
dc.identifier.startpage | 7057 | |
dc.identifier.startpage | 7057 | en_US |
dc.identifier.endpage | 7071 | en_US |
dc.authorid | 0000-0001-9837-0779 | - |
dc.identifier.doi | 10.1021/ic100781v | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.pmid | 20583756 | en_US |
dc.identifier.scopus | 2-s2.0-77954961278 | en_US |
dc.identifier.wos | WOS:000280365300046 | en_US |
dc.identifier.scopusquality | Q1 | - |
dc.owner | Pamukkale University | - |
item.languageiso639-1 | en | - |
item.openairetype | Article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
Appears in Collections: | Fen-Edebiyat Fakültesi Koleksiyonu PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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