Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/6360
Title: Protective effects of ibuprofen against caustic esophageal burn injury in rats
Authors: Herek, Özkan
Karabul, M.
Yenisey, Ç.
Erkuş, M.
Keywords: Caustic ingestion
Corrosive esophageal burn
Esophageal burn
Ibuprofen
Treatment
collagen
hydroxyproline
ibuprofen
isotonic solution
placebo
sodium chloride
sodium hydroxide
animal experiment
animal model
animal tissue
article
controlled study
drug efficacy
esophagus burn
esophagus stenosis
histopathology
male
nonhuman
priority journal
protection
rat
rating scale
sham procedure
Animals
Anti-Inflammatory Agents, Non-Steroidal
Burns, Chemical
Caustics
Esophageal Stenosis
Esophagus
Male
Random Allocation
Rats
Treatment Outcome
Wound Healing
Abstract: Purpose: The aim of this study was to investigate the efficacy of ibuprofen on the healing of esophagus and the prevention of stricture development after esophageal caustic injuries in rats. Materials and methods: Rats were divided into three groups as: group 1(sham), group 2(esophageal burn injury), group 3(injury + ibuprofen). In groups 2 and 3, a standard esophageal burn injury was created by applying 10% NaOH solution to distal esophagus of about 3 cm. To rats in the sham group, isotonic solution was given instead of NaOH. Ibuprofen (90 mg/kg/day) was given via oral route to group 3 rats. Normal saline as placebo was given via the same route to rats in groups 1 and 2. 28 days later, all the live rats were killed. The distal esophageal segments of all rats were removed and divided into two equal parts for biochemical and histopathologic examination. In the tissue samples, biochemically hydroxyproline and histopathologically collagen content and stenosis indices were evaluated for efficacy of treatment. Results: The hydroxyproline level (µg/mg wet tissue) in the groups was 1.54 ± 0.08, 4.82 ± 0.60, and 3.28 ± 0.27, respectively. The hydroxyproline level increased significantly in group 2 compared with group 1 (P < 0.01). Although the hydroxyproline level was significantly increased in group 3 compared with group 1, it decreased significantly in group 3 compared with group 2 (P < 0.05) by treatment of ibuprofen. In group 3, the collagen content score (1.50 ± 0.26) was significantly lower than in group 2 (2.62 ± 0.37) (P < 0.05). The stenosis index was found as 0.37 ± 0.02 in group 1, 0.84 ± 0.02 in group 2, and 0.67 ± 0.03 in group 3. The stenosis index in group 2 was significantly higher than group 1 and group 3 (P < 0.01). Although the stenosis index was significantly higher than in group 1, a significant decrease in stenosis index was found in group 3 compared with group 2, by ibuprofen treatment (P < 0.01). Conclusion: Based on these results, we concluded that the treatment with ibuprofen in acute phase esophageal burn injury has beneficial effects on healing of esophagus and may decrease the stricture formation. For these reasons, ibuprofen may effectively be used in the acute phase treatment of caustic esophagus injury and after esophageal dilatation procedures. © 2010 Springer-Verlag.
URI: https://hdl.handle.net/11499/6360
https://doi.org/10.1007/s00383-010-2618-1
ISSN: 0179-0358
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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