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https://hdl.handle.net/11499/6384
Title: | Effects of retinoic acid and zinc on the treatment of caustic esophageal burns | Authors: | Çorduk, Nergül Koltuksuz, Uğur Çallı Demirkan, Neşe Rota, Simin Abban, Gülçin Sarıoğlu-Buke, Akile |
Keywords: | Esophageal burn Fibrosis Inflammation Retinoic acid TGF-ß1 Zinc caustic agent hydroxyproline retinoic acid transforming growth factor beta1 zinc animal experiment animal model animal tissue antiinflammatory activity antioxidant activity article caustic burn contrast enhancement controlled study drug effect esophagography esophagus burn esophagus stricture histopathology nonhuman priority journal rat Animals Anti-Inflammatory Agents Antioxidants Burns, Chemical Caustics Disease Models, Animal Esophageal Stenosis Esophagus Oxidative Stress Rats Rats, Wistar Tretinoin Zinc Sulfate |
Abstract: | Purpose An experimental study was carried out to investigate the efficacy of an anti-inflammatory and antiproliferative agent all-trans retinoic acid (ATRA) and an antioxidant agent zinc sulphate (ZnSO4) in the prevention of stricture after caustic esophageal burn in rats. Methods Esophageal burn was induced using 50% NaOH. Rats were divided into four groups as follows: group A (sham; n = 8), group B (control; n = 8), group C (treated with ATRA; n = 8) and group D (treated with ZnSO4; n = 8). All rats were killed on the 28th day and esophageal tissues were evaluated for histopathologic damage score, hydroxyproline (HP) content and TGF-ß1 expression. Results Significant difference was detected in terms of histopathologic damage score between groups B and C (p = 0.002). Although mean HP levels of groups C and D were lower than group B, statistical comparison was not significant. TGF-ß1 expression in group C was significantly lower than group B. Conclusion Zinc has not been found effective in the prevention of stricture formation. The results indicate that ATRA has a preventive effect in the development of fibrosis in an experimental model of caustic esophageal burns in rats. © Springer-Verlag 2010. | URI: | https://hdl.handle.net/11499/6384 https://doi.org/10.1007/s00383-010-2571-z |
ISSN: | 0179-0358 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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