Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/6384
Title: Effects of retinoic acid and zinc on the treatment of caustic esophageal burns
Authors: Çorduk, Nergül
Koltuksuz, Uğur
Çallı Demirkan, Neşe
Rota, Simin
Abban, Gülçin
Sarıoğlu-Buke, Akile
Keywords: Esophageal burn
Fibrosis
Inflammation
Retinoic acid
TGF-ß1
Zinc
caustic agent
hydroxyproline
retinoic acid
transforming growth factor beta1
zinc
animal experiment
animal model
animal tissue
antiinflammatory activity
antioxidant activity
article
caustic burn
contrast enhancement
controlled study
drug effect
esophagography
esophagus burn
esophagus stricture
histopathology
nonhuman
priority journal
rat
Animals
Anti-Inflammatory Agents
Antioxidants
Burns, Chemical
Caustics
Disease Models, Animal
Esophageal Stenosis
Esophagus
Oxidative Stress
Rats
Rats, Wistar
Tretinoin
Zinc Sulfate
Abstract: Purpose An experimental study was carried out to investigate the efficacy of an anti-inflammatory and antiproliferative agent all-trans retinoic acid (ATRA) and an antioxidant agent zinc sulphate (ZnSO4) in the prevention of stricture after caustic esophageal burn in rats. Methods Esophageal burn was induced using 50% NaOH. Rats were divided into four groups as follows: group A (sham; n = 8), group B (control; n = 8), group C (treated with ATRA; n = 8) and group D (treated with ZnSO4; n = 8). All rats were killed on the 28th day and esophageal tissues were evaluated for histopathologic damage score, hydroxyproline (HP) content and TGF-ß1 expression. Results Significant difference was detected in terms of histopathologic damage score between groups B and C (p = 0.002). Although mean HP levels of groups C and D were lower than group B, statistical comparison was not significant. TGF-ß1 expression in group C was significantly lower than group B. Conclusion Zinc has not been found effective in the prevention of stricture formation. The results indicate that ATRA has a preventive effect in the development of fibrosis in an experimental model of caustic esophageal burns in rats. © Springer-Verlag 2010.
URI: https://hdl.handle.net/11499/6384
https://doi.org/10.1007/s00383-010-2571-z
ISSN: 0179-0358
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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