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https://hdl.handle.net/11499/6392
Title: | What would be left behind if subtotal thyroidectomy were preferred instead of total thyroidectomy? | Authors: | Tekin, K. Yılmaz, Sevda Yalçın, Nagihan Çoban, Ş. Aydin, Ç. Kabay, Burhan Erdem, Ergün |
Keywords: | Ki-67 antigen MIB-1 antibody Multinodular goiter Subtotal thyroidectomy Thyroid carcinoma Total thyroidectomy adult article clinical article comparative study controlled study female histopathology human human tissue male outcome assessment priority journal staining subtotal thyroidectomy thyroid nodule thyroid papillary carcinoma thyroidectomy tissue growth Carcinoma, Papillary Female Goiter Humans Immunohistochemistry Male Middle Aged Neoplasm, Residual Statistics, Nonparametric Thyroid Neoplasms Thyroidectomy Treatment Outcome |
Abstract: | Background: The choice between subtotal thyroidectomy (STT) and total thyroidectomy (TT) for multinodular goiter (MNG) remains controversial. Methods: Thyroid tissue samples of 34 patients who underwent TT for multinodular disease between October 2005 and June 2007 in Pamukkale University Hospital, Department of General Surgery were evaluated. Thyroid tissues weighing 2 g each from either side were separated from the main specimen to simulate the tissues that would be left behind if a subtotal resection were performed instead of a total resection. Ki-67 staining was performed. Results: The mean age of subjects was 49.3 ± 12 years and 25 (73.5%) were females. Papillary microcarcinomas were found in 4 patients, 1 of which was in a residual thyroid specimen (RTS). Micronodule formations were found in 73.5% of specimens simulating residual thyroid. While Ki-67 indexes of residual thyroid tissues were 4.65% in nodules and 1.91% in normal areas (P < .05), they were 5.42% and 2.84%, respectively, for nodular and normal areas in the main specimens (P < .05). Conclusion: Remnant thyroid tissues, following STT, have a high percentage of micronodule formation with a remarkable cellular proliferative activity. © 2010 Elsevier Inc. All rights reserved. | URI: | https://hdl.handle.net/11499/6392 https://doi.org/10.1016/j.amjsurg.2009.02.005 |
ISSN: | 0002-9610 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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