Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/6392
Title: What would be left behind if subtotal thyroidectomy were preferred instead of total thyroidectomy?
Authors: Tekin, K.
Yılmaz, Sevda
Yalçın, Nagihan
Çoban, Ş.
Aydin, Ç.
Kabay, Burhan
Erdem, Ergün
Keywords: Ki-67 antigen
MIB-1 antibody
Multinodular goiter
Subtotal thyroidectomy
Thyroid carcinoma
Total thyroidectomy
adult
article
clinical article
comparative study
controlled study
female
histopathology
human
human tissue
male
outcome assessment
priority journal
staining
subtotal thyroidectomy
thyroid nodule
thyroid papillary carcinoma
thyroidectomy
tissue growth
Carcinoma, Papillary
Female
Goiter
Humans
Immunohistochemistry
Male
Middle Aged
Neoplasm, Residual
Statistics, Nonparametric
Thyroid Neoplasms
Thyroidectomy
Treatment Outcome
Abstract: Background: The choice between subtotal thyroidectomy (STT) and total thyroidectomy (TT) for multinodular goiter (MNG) remains controversial. Methods: Thyroid tissue samples of 34 patients who underwent TT for multinodular disease between October 2005 and June 2007 in Pamukkale University Hospital, Department of General Surgery were evaluated. Thyroid tissues weighing 2 g each from either side were separated from the main specimen to simulate the tissues that would be left behind if a subtotal resection were performed instead of a total resection. Ki-67 staining was performed. Results: The mean age of subjects was 49.3 ± 12 years and 25 (73.5%) were females. Papillary microcarcinomas were found in 4 patients, 1 of which was in a residual thyroid specimen (RTS). Micronodule formations were found in 73.5% of specimens simulating residual thyroid. While Ki-67 indexes of residual thyroid tissues were 4.65% in nodules and 1.91% in normal areas (P < .05), they were 5.42% and 2.84%, respectively, for nodular and normal areas in the main specimens (P < .05). Conclusion: Remnant thyroid tissues, following STT, have a high percentage of micronodule formation with a remarkable cellular proliferative activity. © 2010 Elsevier Inc. All rights reserved.
URI: https://hdl.handle.net/11499/6392
https://doi.org/10.1016/j.amjsurg.2009.02.005
ISSN: 0002-9610
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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