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https://hdl.handle.net/11499/6394
Title: | Angiotensin converting enzyme gene insertion/deletion polymorphism in patients with polycystic ovary syndrome | Authors: | Karabulut, Aysun Turgut, Sebahat Turgut, Günfer |
Keywords: | Angiotensin converting enzyme gene Insulin resistance Ovary Polycystic ovary syndrome Polymorphism dipeptidyl carboxypeptidase glucose insulin testosterone adult allele article body mass clinical article controlled study female gene amplification gene deletion gene frequency gene insertion genetic polymorphism genotype glucose blood level homeostasis human insulin blood level insulin resistance ovary polycystic disease pathophysiology polymerase chain reaction priority journal testosterone blood level Adult Female Humans Insulin Resistance Peptidyl-Dipeptidase A Polycystic Ovary Syndrome Polymorphism, Genetic Prospective Studies Young Adult |
Abstract: | Objective. The aim of this study is to investigate the relevance of polymorphism in angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism to the pathophysiology of polycystic ovary syndrome (PCOS). Subjects and methods. Thirty patients with PCOS by Rotterdam consensus criteria and 33 control subjects were prospectively investigated. ACE gene amplification of DNA was performed by polymerase chain reaction. Homeostatic model assessment (HOMA-IR) was applied. Results. Compared to controls, ACE gene DD genotype and D allele were observed more frequently in PCOS (63% vs. 46% for DD genotype and 75% vs. 67% for D allele) (p>0.05). Body mass index, fasting glucose and insulin levels, HOMA-IR index and total testosterone levels were higher in PCOS group (p<0.05). The frequencies of D and I alleles were 45 (75%) and 15 (25%) for PCOS group and 44 (67%) and 22 (33%) for control group (p>0.05). No significant differences were observed in the genotype and allele distributions between cases and control groups. HOMA-IR index was significantly higher in patients with PCOS with DD genotype than those with II genotype (p<0.05). Conclusion. The ACE gene polymorphism was not associated with PCOS. However, the presence of D allele was associated with higher rate of insulin resistance in patients with PCOS. © 2010 Informa UK Ltd. | URI: | https://hdl.handle.net/11499/6394 https://doi.org/10.3109/09513591003632167 |
ISSN: | 0951-3590 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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