Synthesis, crystal structure and conformational analysis of (E)-5-methoxy2-((4-methoxyphenylimino)methyl)phenol

Abstract

The title compound, (E)-5-memoxy-2-((4-memoxyphenylimino)methyl)phenol (C15H15NO3), crystallizes in monoclinic, space group P21/c with a = 9.4361(6), b = 10.6212(5), c = 12.9338(9) Å, ß = 93.064(5)°, V= 1294.41(14) Å3, Z = 4, Dc = 1.320 g/cm3, F(000) = 544, Rint = 0.116, T= 296 K, = 0.09 mm-1, the final R = 0.051 and wR = 0.148 for 1836 observed reflections with I > 2?(I). An extensive two-dimensional network of C-H-O hydrogen bonds and ?-ring interactions are responsible for the crystal stabilization. Intermolecular hydrogen bonds and C-H-? interactions produce R22(14), R44(30) and R4 4(31) rings. In addition to the molecular geometry from X-ray experiment, the molecular geometry of the title compound in the ground state has been calculated using the semi-empirical (AMI and PM3) and density functional theory method (DFT) (B3LYP) with 6-31G(d) basis set. To determine the conformational flexibility, molecular energy profile of the title compound was obtained by semi-empirical (PND and AMI) and DFT/B3LYP calculations with respect to the selected degree of torsional freedom, which varied from -180° to +180° in a step of 10°.