Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/6422
Title: Decreased plasma adiponectin concentrations in patients with syndrome X
Authors: Susam, I.
Yaylalı, Yalın Tolga
Dursunoglu, Dursun
Göksoy, H.
Öztürk, M.
Yaylalı, Olga
Semiz, E.
Keywords: Adiponectin
Coronary artery disease
Coronary risk
Syndrome X
adiponectin
cholesterol
high density lipoprotein cholesterol
lipid
low density lipoprotein cholesterol
triacylglycerol
adult
angiocardiography
article
body mass
cholesterol blood level
clinical article
controlled study
exercise test
female
heart muscle perfusion
human
male
non invasive procedure
protein blood level
rank sum test
single photon emission computer tomography
stable angina pectoris
syndrome X
Adult
Aged
Algorithms
Angina Pectoris
Biological Markers
Body Mass Index
Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography
Case-Control Studies
Cholesterol
Cholesterol, HDL
Cholesterol, LDL
Coronary Angiography
Endothelium, Vascular
Exercise Test
Female
Humans
Male
Metabolic Syndrome X
Middle Aged
Risk Factors
Tomography, Emission-Computed, Single-Photon
Triglycerides
Abstract: Objective - The levels of adiponectin, an anti-atherogenic protein, are decreased in patients with coronary artery disease. Syndrome X is associated with endothelial dysfunction, which is a key feature in the evolution of atherosclerosis. We sought to determine whether serum adiponectin levels are decreased in patients with syndrome X. Methods - Twenty-three syndrome X patients (14 men, 9 women) who presented with stable angina pectoris, had a positive non-invasive stress test or an abnormal myocardial perfusion scintigraphy single photon emission computed tomography (MPS SPECT) and a normal coronary angiogram, were included in our study, as were 17 asymptomatic healthy subjects (13 men, 4 women) with normal results from non-invasive stress testing. The serum adiponectin levels and lipid profiles of the patients and control subjects were determined with venous samples collected after a 12-hour fast. The results were analysed by a Mann Whitney U test. Results - Mean age (54.1 ± 11.8 y in patients and 59.8 ± 9.6 y in control subjects, P > 0.05) and body mass index (28.0 ± 3.3 in patients and 27.1 ± 4.2 in control subjects, P > 0.05) did not differ between the two groups. Adiponectin levels in patients with syndrome X (1.5 ± 1.1 µg/dl) were significantly lower than those in the control group (5.3 ± 2.9 µg/dl, P < 0.0001). Serum total cholesterol (TCHOL), triglyceride (TG), LDL, and HDL-cholesterol levels did not differ between the two groups (P > 0.05). Conclusion - Serum adiponectin levels were lower in patients with syndrome X, and these low adiponectin concentrations may cause endothelial dysfunction. Thus, patients with a marked drop in adiponectin levels may be considered at high risk for future coronary events and may therefore benefit from additional pharmacological treatment.
URI: https://hdl.handle.net/11499/6422
https://doi.org/10.2143/AC.65.2.2047056
ISSN: 0001-5385
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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