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https://hdl.handle.net/11499/6422
Title: | Decreased plasma adiponectin concentrations in patients with syndrome X | Authors: | Susam, I. Yaylalı, Yalın Tolga Dursunoglu, Dursun Göksoy, H. Öztürk, M. Yaylalı, Olga Semiz, E. |
Keywords: | Adiponectin Coronary artery disease Coronary risk Syndrome X adiponectin cholesterol high density lipoprotein cholesterol lipid low density lipoprotein cholesterol triacylglycerol adult angiocardiography article body mass cholesterol blood level clinical article controlled study exercise test female heart muscle perfusion human male non invasive procedure protein blood level rank sum test single photon emission computer tomography stable angina pectoris syndrome X Adult Aged Algorithms Angina Pectoris Biological Markers Body Mass Index Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography Case-Control Studies Cholesterol Cholesterol, HDL Cholesterol, LDL Coronary Angiography Endothelium, Vascular Exercise Test Female Humans Male Metabolic Syndrome X Middle Aged Risk Factors Tomography, Emission-Computed, Single-Photon Triglycerides |
Abstract: | Objective - The levels of adiponectin, an anti-atherogenic protein, are decreased in patients with coronary artery disease. Syndrome X is associated with endothelial dysfunction, which is a key feature in the evolution of atherosclerosis. We sought to determine whether serum adiponectin levels are decreased in patients with syndrome X. Methods - Twenty-three syndrome X patients (14 men, 9 women) who presented with stable angina pectoris, had a positive non-invasive stress test or an abnormal myocardial perfusion scintigraphy single photon emission computed tomography (MPS SPECT) and a normal coronary angiogram, were included in our study, as were 17 asymptomatic healthy subjects (13 men, 4 women) with normal results from non-invasive stress testing. The serum adiponectin levels and lipid profiles of the patients and control subjects were determined with venous samples collected after a 12-hour fast. The results were analysed by a Mann Whitney U test. Results - Mean age (54.1 ± 11.8 y in patients and 59.8 ± 9.6 y in control subjects, P > 0.05) and body mass index (28.0 ± 3.3 in patients and 27.1 ± 4.2 in control subjects, P > 0.05) did not differ between the two groups. Adiponectin levels in patients with syndrome X (1.5 ± 1.1 µg/dl) were significantly lower than those in the control group (5.3 ± 2.9 µg/dl, P < 0.0001). Serum total cholesterol (TCHOL), triglyceride (TG), LDL, and HDL-cholesterol levels did not differ between the two groups (P > 0.05). Conclusion - Serum adiponectin levels were lower in patients with syndrome X, and these low adiponectin concentrations may cause endothelial dysfunction. Thus, patients with a marked drop in adiponectin levels may be considered at high risk for future coronary events and may therefore benefit from additional pharmacological treatment. | URI: | https://hdl.handle.net/11499/6422 https://doi.org/10.2143/AC.65.2.2047056 |
ISSN: | 0001-5385 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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