Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/6438
Title: Peripheral neuropathy in chronic obstructive pulmonary disease
Authors: Öncel, Çağatay Hilmi
Başer Öncel, Sevin
Çam, M.
Şahin, Beyza
Taspinar, B.
Evyapan, F.
Keywords: COPD
Peripheral neuropathy
Proinflammatory cytokines
C reactive protein
interleukin 6
somatomedin C
tumor necrosis factor alpha
abductor muscle
action potential
adult
article
chronic obstructive lung disease
clinical article
controlled study
dynamometry
extensor muscle
female
flexor muscle
forced expiratory volume
human
latent period
male
motor nerve conduction
muscle strength
peripheral neuropathy
peroneal neuropathy
polyneuropathy
priority journal
protein blood level
sensory nerve conduction
skeletal muscle
sural nerve
tibial nerve
ulnar nerve
Action Potentials
Aged
C-Reactive Protein
Case-Control Studies
Cohort Studies
Cytokines
Female
Humans
Male
Middle Aged
Neural Conduction
Peripheral Nervous System Diseases
Prevalence
Pulmonary Disease, Chronic Obstructive
Abstract: The aim of this study was to evaluate the frequency and characteristics of peripheral nervous system involvement in chronic obstructive pulmonary disease and its relation with proinflammatory cytokines such as TNF-?, IL-6, IGF-1 and CRP. Forty chronic obstructive pulmonary disease patients with a mean age 62.8 ± 5.5 years and 33 healthy controls with a mean age of 61.8 ± 7.4 were included into this study. All subjects were evaluated with standard motor and sensory nerve conduction studies. Serum TNF-?, IL-6, CRP and IGF-1 were measured. The muscle strengths of three muscle groups (knee extensors, shoulder abductors and flexors) were assessed with a hand-held dynamometer. Peripheral neuropathy was detected at 15 of chronic obstructive pulmonary disease patients. Ulnar motor and sensory nerves, left sural nerve distal latencies were found significantly prolonged than healthy volunteers (p 0.011), peroneal nerve conduction velocities was found lower in patients than in healthy controls (p 0.021), tibial nerve amplitudes was found lower in patients than healthy controls (p 0.046). CRP and TNF-? were found significantly higher in chronic obstructive pulmonary disease patients and IGF-1 was found significantly lower in chronic obstructive pulmonary disease patients. There was no correlations between proinflammatory cytokines, CRP and electrophysiological findings. Left sural nerve's sensory nerve action potential amplitude was correlated positively with FEV1 (r 0.425; p 0.009). Muscle strength at the shoulder and knee were significantly reduced in patients with COPD when compared with controls. The frequency of neuropathy was higher in chronic obstructive pulmonary disease when compared with the healthy controls. Chronic obstructive pulmonary disease patients have subclinical peripheral nerve involvements. © Copyright © 2010 Informa Healthcare USA, Inc.
URI: https://hdl.handle.net/11499/6438
https://doi.org/10.3109/15412550903499480
ISSN: 1541-2555
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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