Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/6443
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dc.contributor.authorŞengül, C.-
dc.contributor.authorErdal, M.E.-
dc.contributor.authorAydin, N.-
dc.contributor.authorBalci Şengül, C.-
dc.contributor.authorBarlas, Ö.-
dc.contributor.authorAynacioglu, Ş.-
dc.contributor.authorHerken, H.-
dc.date.accessioned2019-08-16T12:07:24Z-
dc.date.available2019-08-16T12:07:24Z-
dc.date.issued2010-
dc.identifier.issn1302-6631-
dc.identifier.urihttps://hdl.handle.net/11499/6443-
dc.description.abstractObjective: Antipsychotic induced weight gain is a major problem for second generation antipsychotics which may lead to diabetes and metabolic syndrome. Recent studies were mentioning that genetic factors might be relevant in antipsychotic induced weight gain. Aim of this study is evaluation of the association between IRS-1 Glyp972Arg polymorphism and olanzapine induced weight gain. Methods: Total of 95 patients whom were diagnosed as schizophrenia by DSM-IV criteria were included to study. Body weight, body mass index and blood glucose levels of all patients were checked at the beginning and six weeks after olanzapine treatment. Blood for DNA analysis were obtained from patients and analyzed as mentioned in literature. Data were evaluated with descriptive methods and Mann Whitney U test was used for comparison of two groups. Results: Eighty and four of patients had Glycine/Glycine and 11 patients had Glycine/Arginine genotype of IRS-1 Gly972Arg polymorphism. Despite the patients with Glycine/Glycine polymorphism gained more weight than patients with Glycine/Arginine polymorphism, the difference between Glycine/Glycine and Glycine/Arginine groups for weight change and body mass index change wasn't statistically significant. Conclusion: Our results showed no statistical relationship between the IRS-1 Gly972Arg polymorphism and olanzapine induced weight gain. However exploration of the other IRS genotypes and the antipsychotic-induced body weight change may help in the understanding of the mechanisms of antipsychotic-induced body weight gain.en_US
dc.language.isotren_US
dc.relation.ispartofAnadolu Psikiyatri Dergisien_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIRSen_US
dc.subjectOlanzapineen_US
dc.subjectPharmacogeneticsen_US
dc.subjectWeight gainen_US
dc.subjectarginineen_US
dc.subjectglucoseen_US
dc.subjectglycineen_US
dc.subjectinsulin receptor substrate 1en_US
dc.subjectolanzapineen_US
dc.subjectarticleen_US
dc.subjectblood samplingen_US
dc.subjectbody massen_US
dc.subjectbody weighten_US
dc.subjectcontrolled studyen_US
dc.subjectDNA determinationen_US
dc.subjectgenetic associationen_US
dc.subjectgenotypeen_US
dc.subjectglucose blood levelen_US
dc.subjecthumanen_US
dc.subjectmajor clinical studyen_US
dc.subjectmental patienten_US
dc.subjectmolecular mechanicsen_US
dc.subjectschizophreniaen_US
dc.subjectside effecten_US
dc.subjectsingle nucleotide polymorphismen_US
dc.subjecttreatment durationen_US
dc.subjectweight changeen_US
dc.subjectweight gainen_US
dc.titleThe relation between IRS-1 Gly972Arg (insulin receptor substrate) gene polymorphism and olanzapine induced weight gainen_US
dc.typeArticleen_US
dc.identifier.volume11en_US
dc.identifier.issue1en_US
dc.identifier.startpage18-
dc.identifier.startpage18en_US
dc.identifier.endpage22en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopus2-s2.0-77749341437en_US
dc.identifier.wosWOS:000275055700003en_US
dc.identifier.scopusqualityQ4-
dc.ownerPamukkale University-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.grantfulltextopen-
item.languageiso639-1tr-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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