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https://hdl.handle.net/11499/6518
Title: | IGF-1 gene polymorphism in obese patients with insulin resistance | Authors: | Fidan Yaylalı, Güzin Akın, Fulya Turgut, Sabahat Kurşunluoğlu, Raziye |
Keywords: | IGF-1 gene polymorphisim Insulin resistance Obesity genomic DNA growth hormone insulin somatomedin binding protein 3 somatomedin C adult anthropometry article controlled study DNA polymorphism female genotype human insulin resistance major clinical study male obesity protein blood level thyroid function test Adult Body Mass Index Body Weight Case-Control Studies Female Hormones Humans Insulin Resistance Insulin-Like Growth Factor I Male Polymorphism, Genetic |
Abstract: | IGFs (Insulin like growth factors) are important regulators of pancreatic ß cell development, growth and maintenance. Mutations in the IGF genes have been found to be associated with diabetes mellitus, myocardial infarction obesity. These associations could result from changes in insulin secretion. We aimed to investigate IGF-1 gene polymorphism in obese patients with insulin resistance. We included 100 obese patients with insulin resistance 30 healthy subjects to study. At baseline examinations, antropometric measurements were done. Genomic DNA from the patients and controls were prepared. Thyroid function tests and serum IGFBP3 levels were similar between patients and controls whereas IGF, GH levels were significantly lower in obese patients. We categorized the IGF-1 (CA)19 polymorphism area into 3 groups as lower than 192 bp (group 1), 192-194 bp (group 2), and higher than 194 bp(group 3). Group 3 was more frequent in both obese and control groups. IGF-1 levels were also significantly lower in obese group (138.51 ± 49.3) in than controls (218.14 ± 69.15). IGF-1 levels were significantly lower in obese patients. The most frequent IGF-1 gen polymorphism allel is >194 bp in both obese insulin resistant patients and controls. IGF-1 levels and the other biochemical and hormonal parameters were similar in different genotype groups. The cause of lower IGF-1 levels in obese patients might be different from IGF-1 gene polymorphism and it may be insulin resistance. © 2009 Springer Science+Business Media B.V. | URI: | https://hdl.handle.net/11499/6518 https://doi.org/10.1007/s11033-009-9729-6 |
ISSN: | 0301-4851 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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