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https://hdl.handle.net/11499/6641
Title: | Takayasu's arteritis in Turkey - Clinical and angiographic features of 248 patients | Authors: | Bicakcigil, M. Aksu, K. Kamali, S. Ozbalkan, Z. Ates, A. Karadag, O. Ozer, H.T.E. |
Keywords: | Clinical and angiographic features Prognosis Takayasu's arteritis azathioprine corticosteroid cyclophosphamide leflunomide methotrexate mycophenolic acid 2 morpholinoethyl ester tumor necrosis factor inhibitor adult aged angiography aorta arch syndrome aorta valve regurgitation appetite arthralgia arthritis article blurred vision carotid artery cerebrovascular accident claudication clinical feature clinical protocol controlled study demography disease classification dyspnea erythema nodosum female fever follow up headache heart infarction heart palpitation human hypertension kidney artery stenosis limb pain major clinical study male pericarditis priority journal prognosis prospective study pulmonary hypertension Raynaud phenomenon remission renal artery subclavian artery syncope thorax pain turkey (bird) weakness weight reduction Adolescent Adult Age of Onset Aged Angiography Child Comorbidity Drug Therapy, Combination Female Glucocorticoids Humans Immunosuppressive Agents Male Middle Aged Prospective Studies Remission Induction Takayasu Arteritis Turkey Young Adult |
Abstract: | Objective. Takayasu's arteritis (TA) is a chronic, inflammatory vasculitis affecting the aorta and its major branches. Although it is more prevalent in Far-East Asia, the distribution of the disease is worldwide with different vascular involvement patterns and clinical manifestations. The objective of this study was to evaluate the demographic, clinical, angiographic and prognostic features of TA patients in Turkey. Methods. Clinical and angiographic findings of 248 TA patients (228 female, 27 male) followed at 15 Rheumatology Centers were prospectively evaluated according to a predefined protocol. Results. The mean age was 40.1 years (30.2 years at the clinical onset). Clinical manifestations included constitutional symptoms in 66%, absent or diminished pulses in 88%, bruits in 77%, extremity pain in 69%, claudication in 48%, hypertension in 43% and cerebrovascular accidents (CVA) in 18% of the patients. Renal artery stenosis, aortic regurgitation and pulmonary hypertension were present in 26%, 33% and 12%, respectively. According to the new angiographic classification, type V (50.8%) and Type I (32%) were the most frequent types of involvement. Corticosteroids were the main treatment in 93% of the patients alone (9%) or in combination with immunosuppressive agents (84%). Most frequently preferred immunosuppressive agents were methotrexate (63%), azathioprine (22%) and cyclophosphamide (13%). Remission was observed at least once in 94% of the patients and sustained remission in 71% during follow-up. Conclusion. The demographical, clinical and angiographic findings of TA patients in our series were similar to those reported from Japan, Brazil and Colombia. Combination therapies with immunosuppressive agents were the preferred choice of treatment in Turkey. © Copyright Clinical and Experimental Rheumatology 2009. | URI: | https://hdl.handle.net/11499/6641 | ISSN: | 0392-856X |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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