Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/6669
Title: From genetics to epigenetics: Alcohol addiction
Authors: Şengül, Cem
Herken, Hasan
Keywords: Alcohol addiction
Epigenetics
Genetics
Polymorphism
aldehyde dehydrogenase
alcoholism
brain region
dopaminergic system
epigenetics
GABAergic system
gene expression
genetic polymorphism
genetic risk
genetics
human
pathogenesis
review
serotoninergic system
Abstract: Alcohol addiction is a chronic, relapsing disorder with a huge societal impact. Understanding the genetic basis of alcohol addiction is crucial to characterize individuals' risk and to develop efficacious prevention and treatment strategies. Recent studies have also begun to focus on the molecular mechanisms and epigenetics of alcohol addiction. Changes in gene expression in brain reward regions are thought to contribute to the pathogenesis and persistence of drug addiction. Data from classical genetic studies to new epigenetic studies could show us new dimensions of alcohol addiction. Data from genetic studies also guide pharmacotherapeutic agent choice for optimum treatment of alcohol addiction. In this review, we examined the Pubmed database, using alcoholism, genetics, epigenetics and polymorphism key words and than discussed results of studies.
URI: https://hdl.handle.net/11499/6669
ISSN: 1302-6631
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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