Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/6853
Title: Association between cholesterols, homocysteine and silent brain infarcts
Authors: Öncel, Çağatay
Demir, Süleyman
Güler, Sibel
Cenikli, Utku
Tabak, Ertan
Kıroglu, Yılmaz
Keywords: Brain infarct
Cholesterol
Homocysteine
cholesterol
cyanocobalamin
folic acid
high density lipoprotein cholesterol
homocysteine
low density lipoprotein cholesterol
very low density lipoprotein cholesterol
adult
aged
article
brain infarction
cholesterol blood level
disease association
female
human
hypercholesterolemia
hyperhomocysteinemia
major clinical study
male
multivariate logistic regression analysis
nuclear magnetic resonance imaging
priority journal
sex difference
stroke
transient ischemic attack
Adult
Aged
Aged, 80 and over
Blood Chemical Analysis
Brain Infarction
Cardiovascular Diseases
Cross-Sectional Studies
Female
Folic Acid
Humans
Lipoproteins, LDL
Magnetic Resonance Imaging
Male
Middle Aged
Risk Factors
Sex Factors
Vitamin B 12
Young Adult
Abstract: Background The aim of this study was to assess the relationship between total plasma homocysteine, cholesterol levels, vitamin B12, folate, thyroid hormones, urea, ferritin, uric acid, C-reactive protein, cardiovascular risk factors and silent brain infarct (SBI) in patients without any neurological disorder. Whether the factors of interest were associated with SBI is investigated. Methods One hundred and forty-two subjects with a mean age of 52.1 ± 13.1 years (21-87 years) without any history of stroke, transient ischaemic attack and neurological abnormality were enrolled in this cross-sectional study. The subjects underwent brain magnetic resonance imaging and blood chemistry determinations. Student's t-test was used to compare differences in means of laboratory results between the groups with and without SBI. The ?2-test was used for categorized variables. Multiple logistic regression analysis was used to determine the independent predictors of SBI. Results The group comprised 56 men and 86 women. SBI were found in 40 patients (28%). The low-density lipoprotein levels were significantly higher in the infarct group (P = 0.019), homocysteine concentrations were significantly higher in the men-infarct group (P = 0,029) and total cholesterol levels were significantly higher in the women-infarct group than the women non-infarct group (P = 0.006). Conclusion Serum low-density lipoprotein, total cholesterol and homocysteine levels were associated with SBI. © 2009 The Authors Journal compilation © 2009 Royal Australasian College of Physicians.
URI: https://hdl.handle.net/11499/6853
https://doi.org/10.1111/j.1445-5994.2008.01802.x
ISSN: 1444-0903
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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