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https://hdl.handle.net/11499/7028
Title: | Associations of alcohol consumption with blood pressure, lipoproteins, and subclinical inflammation among Turks | Authors: | Onat, A. Hergenc, G. Dursunoğlu, Dursun Ordu, S. Can, G. Bulur, S. Yüksel, H. |
Keywords: | Alcohol consumption Apolipoprotein B Blood pressure C-reactive protein LDL cholesterol Metabolic syndrome alcohol apolipoprotein B C reactive protein low density lipoprotein cholesterol triacylglycerol adult alcohol consumption article blood pressure measurement cardiovascular risk cholesterol blood level controlled study correlation analysis diastolic blood pressure drinking behavior female human inflammation linear regression analysis lipoprotein blood level logistic regression analysis major clinical study male metabolic disorder prospective study protein blood level risk assessment risk reduction sex difference systolic blood pressure triacylglycerol blood level Turkey (republic) Adult Alcohol Drinking Blood Pressure C-Reactive Protein Cross-Sectional Studies Female Follow-Up Studies Humans Hypertension Inflammation Lipoproteins Male Middle Aged Prospective Studies Risk Factors Sex Factors Turkey |
Abstract: | Gender-related impact of alcohol consumption on blood pressure (BP), serum lipoprotein profile, and C-reactive protein (CRP) concentrations was evaluated prospectively. Alcohol drinking status was assessed as abstainers and categories of light, moderate, and heavy (daily >40 ml ethanol) intake. Mean age of the 3,443 men and women who were followed up for a mean of 7.4 years was 47.6 ± 12 years. In each multivariable linear or logistic regression analysis, alcohol drinking status was adjusted for age, sex, smoking status, and physical activity. Among men, drinking was significantly associated positively with low-density lipo protein (LDL) cholesterol, apolipoprotein (apo) B, systolic and diastolic BP, and with CRP in a log-linear manner exhibiting features of a threshold at heavy drinking. With respect to response of serum triglycerides to light-to-moderate drinking, whereas men exhibited a significant increase, women exhibited a decline (P < .05). Lower BPs (P < .03) and CRP levels (P = .032) were observed in female drinkers than abstainers and, as distinct from men, no increases in LDL cholesterol and apoB were noted. Heavy drinking tended to protect the sexes against the risk of developing low high-density lipoprotein cholesterol levels in prospective multi adjusted analyses. Sex modulates response of cardiometabolic risk variables to moderate alcohol consumption among Turks. Only women respond with lower triglycerides and CRP, whereas men show a log-linear positive association of drinking categories with BP, LDL cholesterol, apoB, and CRP. © 2008 Elsevier Inc. All rights reserved. | URI: | https://hdl.handle.net/11499/7028 https://doi.org/10.1016/j.alcohol.2008.06.007 |
ISSN: | 0741-8329 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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