Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/7046
Title: Investigation of hepatitis G virus prevalence in hemodialysis patients and blood donors in Denizli, Turkey
Authors: Yilmaz Hanci, S.
Cevahir, Nural
Kaleli, İlknur
Hanci, V.
Keywords: Blood donor
GBV-C/HGV
Haemodialysis
RT-PCR
Turkey
virus antibody
virus RNA
adult
article
blood
blood donor
comparative study
enzyme immunoassay
female
genetics
Hepatitis G virus
human
immunology
isolation and purification
male
middle aged
prevalence
renal replacement therapy
reverse transcription polymerase chain reaction
Turkey (republic)
virus hepatitis
virus infection
Adult
Antibodies, Viral
Blood Donors
Female
Flaviviridae Infections
GB virus C
Hepatitis, Viral, Human
Humans
Immunoenzyme Techniques
Male
Middle Aged
Prevalence
Renal Dialysis
Reverse Transcriptase Polymerase Chain Reaction
RNA, Viral
Abstract: This study focuses on the prevalence of hepatitis G virus (GBV-C/HGV) in hemodialysis patients and blood donors in Denizli (located at Aegean region of Turkey). A total of 100 patients (mean age: 56.8 ± 13.3 years; 46 female) receiving hemodialysis and 100 blood donors (mean age: 31.3 ± 8.1 years; 8 female) were included in the study. The presence of GBV-C/HGV RNA was determined in all patients by reverse transcriptase-PCR and the presence of GBV-C/HGV anti-E2 antibodies was determined by a commercial enzyme immunoassay (Diagnostic Automation, INC®). Viral RNA positivity was determined in 14 (14%) of the hemodialysis patients and 2 (2%) of the blood donors, the difference being statistically significant (p< 0.05). GBV-C/HGV anti-E2 antibodies were detected in 1 (1%) of the hemodialysis patients and 3 (3%) of the blood donors. Anti-E2 positive patient also revealed positive result for viral RNA. There was no statistically significant difference between the two groups in terms of anti-E2 positivity. The prevalence of GBV-C/HGV was 14% in hemodialysis patients and 5% in blood donors (p< 0.05). There was no significant difference in terms of duration of hemodialysis, serum ALT levels, age or gender between GBV-C /HGV positive and negative hemodialysis patients. In conclusion, since hemodialysis patients are at an increased risk of parenteral transmission, they have significantly higher GBV-C/HGV viremia rates and prevalence when compared to blood donors. However, the prevalence of GBV-C/HGV and coexistence between GBV-C/HGV and hepatitis C virus have been decreasing in our region owing to increased hygienic precautions in hemodialysis units, avoidance of unnecessary blood transfusions and more widespread use of erythropoietin.
URI: https://hdl.handle.net/11499/7046
ISSN: 0374-9096
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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