Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/7067
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dc.contributor.authorFeitelson, M.A.-
dc.contributor.authorReis, H.M.G.P.V.-
dc.contributor.authorPan, J.-
dc.contributor.authorClayton, M.-
dc.contributor.authorSun, B.-
dc.contributor.authorSatiroglu-Tufan, N.L.-
dc.contributor.authorLian, Z.-
dc.date.accessioned2019-08-16T12:15:06Z-
dc.date.available2019-08-16T12:15:06Z-
dc.date.issued2008-
dc.identifier.issn1746-0794-
dc.identifier.urihttps://hdl.handle.net/11499/7067-
dc.identifier.urihttps://doi.org/10.2217/17460794.3.5.455-
dc.description.abstractChronic HBV infection is associated with the development of hepatocellular carcinoma (HCC). HBV contributes to tumorigenesis by encoding hepatitis B x antigen (HBxAg), which is a trans-regulatory protein that appears to contribute to HCC by altering patterns of host gene expression. In this review, recent data is presented that outlines some of the putative mechanisms whereby HBxA9 contributes to HCC. With the development of animal models of HBxAg-mediated HCC, the relevance and temporal order of putative steps in this process can now be dissected to elucidate what is rate limiting and when. This will have a profound impact on the design of novel and specific therapeutics for HCC. © 2008 Future Medicine Ltd.en_US
dc.language.isoenen_US
dc.relation.ispartofFuture Virologyen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectFibrosisen_US
dc.subjectHepatitis B x antigenen_US
dc.subjectHepatocellular carcinomaen_US
dc.subjectSenescenceen_US
dc.subjectSignal transductionen_US
dc.subjectSteatosisen_US
dc.subjectTreatmenten_US
dc.subjectTumor suppressorsen_US
dc.subjecthepatitis B virus X proteinen_US
dc.subjectimmunoglobulin enhancer binding proteinen_US
dc.subjectmitogen activated protein kinaseen_US
dc.subjectperoxisome proliferator activated receptor gammaen_US
dc.subjectphosphatidylinositol 3 kinaseen_US
dc.subjectphosphatidylinositol 3,4,5 trisphosphate 3 phosphataseen_US
dc.subjectprotein kinase Ben_US
dc.subjectprotein p53en_US
dc.subjectRaf proteinen_US
dc.subjectRas proteinen_US
dc.subjectsorafeniben_US
dc.subjectsterol regulatory element binding protein 1en_US
dc.subjecttransforming growth factor beta1en_US
dc.subjecttumor necrosis factor alphaen_US
dc.subjectWnt proteinen_US
dc.subjectapoptosisen_US
dc.subjectcancer inhibitionen_US
dc.subjectchronic liver diseaseen_US
dc.subjectdown regulationen_US
dc.subjectenzyme inhibitionen_US
dc.subjectfibrogenesisen_US
dc.subjectgene expression regulationen_US
dc.subjecthepatitisen_US
dc.subjecthepatitis Ben_US
dc.subjectHepatitis B virusen_US
dc.subjecthumanen_US
dc.subjectliver carcinogenesisen_US
dc.subjectliver cell carcinomaen_US
dc.subjectnonhumanen_US
dc.subjectoxidative stressen_US
dc.subjectpriority journalen_US
dc.subjectreviewen_US
dc.subjectupregulationen_US
dc.subjectvirus replicationen_US
dc.subjectAnimaliaen_US
dc.titleHBV X protein: Elucidating a role in oncogenesisen_US
dc.typeReviewen_US
dc.identifier.volume3en_US
dc.identifier.issue5en_US
dc.identifier.startpage455
dc.identifier.startpage455en_US
dc.identifier.endpage470en_US
dc.identifier.doi10.2217/17460794.3.5.455-
dc.relation.publicationcategoryDiğeren_US
dc.identifier.scopus2-s2.0-55849132680en_US
dc.identifier.wosWOS:000259280400010en_US
dc.identifier.scopusqualityQ4-
dc.ownerPamukkale University-
item.languageiso639-1en-
item.openairetypeReview-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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