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https://hdl.handle.net/11499/7073
Title: | Are C-reactive protein and homocysteine cardiovascular risk factors in obese children and adolescents? | Authors: | Semiz, Serap Rota, S. Özdemir, Özmert Özdemir, A. Kaptanoglu, B. |
Keywords: | C-reactive protein Children Homocysteine Leptin Obesity C reactive protein glucose high sensitivity C reactive protein homocysteine insulin leptin lipid unclassified drug adolescent amino acid blood level article atherosclerosis body mass body weight cardiovascular disease cardiovascular risk child childhood disease clinical article diastolic blood pressure female glucose blood level human inflammation insulin blood level insulin resistance lipid blood level male obesity priority journal protein blood level risk assessment risk factor systolic blood pressure Adolescent C-Reactive Protein Child Child, Preschool Coronary Disease Female Humans Male Risk Factors |
Abstract: | Background: Several prospective epidemiological studies have demonstrated that high-sensitivity C-reactive protein (hsCRP) and plasma homocysteine (hcy) are predictors of future coronary events among healthy men and women. The aim of the present study was therefore to investigate a possible relationship between hsCRP, hcy levels and body mass index (BMI), relative weight (RW), serum leptin levels, and cardiovascular risk factors in obese children and adolescents. Methods: The study involved 28 obese children and adolescents (13 girls, 15 boys; BMI>95‰ for age and sex), 4.5-15 years of age (mean 10.7 ± 0.6 years), who attended hospital for a basic obesity check-up. The association between hsCRP, hcy levels and BMI, RW, serum leptin levels, and cardiovascular risk factors such as blood pressure (BP), lipid profile, serum fasting insulin levels, and insulin resistance indexes, was investigated. Results: Serum hsCRP level was positively correlated with BMI (r = 0.512, P < 0.01), RW (r = 0.438, P < 0.05), systolic and diastolic BP (r = 0.498, P < 0.01), serum leptin levels (r = 0.457, P < 0.05), but not with serum lipid, glucose, fasting insulin, plasma hcy levels or insulin resistance indexes. For hcy level, in contrast, no correlation was found with BMI, RW, systolic and diastolic BP, serum lipid levels, leptin, hsCRP, glucose, fasting insulin levels, or insulin resistance indexes. Conclusions: hsCRP is correlated with BMI, RW, BP and leptin, which are risk factors for coronary heart disease, which supports the relationship between obesity, inflammation and atherosclerosis. hsCRP in childhood obesity might be a useful index to predict possible atherosclerotic events. © 2008 Japan Pediatric Society. | URI: | https://hdl.handle.net/11499/7073 https://doi.org/10.1111/j.1442-200X.2008.02615.x |
ISSN: | 1328-8067 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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