Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/7073
Title: Are C-reactive protein and homocysteine cardiovascular risk factors in obese children and adolescents?
Authors: Semiz, Serap
Rota, S.
Özdemir, Özmert
Özdemir, A.
Kaptanoglu, B.
Keywords: C-reactive protein
Children
Homocysteine
Leptin
Obesity
C reactive protein
glucose
high sensitivity C reactive protein
homocysteine
insulin
leptin
lipid
unclassified drug
adolescent
amino acid blood level
article
atherosclerosis
body mass
body weight
cardiovascular disease
cardiovascular risk
child
childhood disease
clinical article
diastolic blood pressure
female
glucose blood level
human
inflammation
insulin blood level
insulin resistance
lipid blood level
male
obesity
priority journal
protein blood level
risk assessment
risk factor
systolic blood pressure
Adolescent
C-Reactive Protein
Child
Child, Preschool
Coronary Disease
Female
Humans
Male
Risk Factors
Abstract: Background: Several prospective epidemiological studies have demonstrated that high-sensitivity C-reactive protein (hsCRP) and plasma homocysteine (hcy) are predictors of future coronary events among healthy men and women. The aim of the present study was therefore to investigate a possible relationship between hsCRP, hcy levels and body mass index (BMI), relative weight (RW), serum leptin levels, and cardiovascular risk factors in obese children and adolescents. Methods: The study involved 28 obese children and adolescents (13 girls, 15 boys; BMI>95‰ for age and sex), 4.5-15 years of age (mean 10.7 ± 0.6 years), who attended hospital for a basic obesity check-up. The association between hsCRP, hcy levels and BMI, RW, serum leptin levels, and cardiovascular risk factors such as blood pressure (BP), lipid profile, serum fasting insulin levels, and insulin resistance indexes, was investigated. Results: Serum hsCRP level was positively correlated with BMI (r = 0.512, P < 0.01), RW (r = 0.438, P < 0.05), systolic and diastolic BP (r = 0.498, P < 0.01), serum leptin levels (r = 0.457, P < 0.05), but not with serum lipid, glucose, fasting insulin, plasma hcy levels or insulin resistance indexes. For hcy level, in contrast, no correlation was found with BMI, RW, systolic and diastolic BP, serum lipid levels, leptin, hsCRP, glucose, fasting insulin levels, or insulin resistance indexes. Conclusions: hsCRP is correlated with BMI, RW, BP and leptin, which are risk factors for coronary heart disease, which supports the relationship between obesity, inflammation and atherosclerosis. hsCRP in childhood obesity might be a useful index to predict possible atherosclerotic events. © 2008 Japan Pediatric Society.
URI: https://hdl.handle.net/11499/7073
https://doi.org/10.1111/j.1442-200X.2008.02615.x
ISSN: 1328-8067
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Show full item record



CORE Recommender

SCOPUSTM   
Citations

16
checked on Nov 30, 2024

WEB OF SCIENCETM
Citations

13
checked on Nov 29, 2024

Page view(s)

50
checked on Aug 24, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.