Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/7092
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dc.contributor.authorOnat, A.-
dc.contributor.authorHergenç, G.-
dc.contributor.authorDursunoglu, Dursun-
dc.contributor.authorKüçükdurmaz, Z.-
dc.contributor.authorBulur, S.-
dc.contributor.authorCan, G.-
dc.date.accessioned2019-08-16T12:15:31Z
dc.date.available2019-08-16T12:15:31Z
dc.date.issued2008-
dc.identifier.issn1449-2288-
dc.identifier.urihttps://hdl.handle.net/11499/7092-
dc.identifier.urihttps://doi.org/10.7150/ijbs.4.208-
dc.description.abstractIt is unclear whether serum adiponectin concentrations diminish linearly with increasing adiposity and, if not, which factors codetermine this association. These issues were investigated cross-sectionally in 1188 men and women, representative of middle-aged and elderly Turkish adults. Serum total adiponectin was assayed by ELISA. Serum adiponectin values in men, though declining significantly in transition from the bottom to the mid tertile of body mass index (BMI) and waist circumference (WC), were similar in the two respective upper tertiles. In women, serum adiponectin concentrations were not significantly different in any tertile of these indices, were significantly correlated with BMI or WC within the low tertiles and not within the two higher tertiles. In a linear regression analysis for WC (or BMI) in a subset of the sample in which serum sex hormone-binding globulin (SHBG) was available and which additionally comprised adiponectin, fasting insulin and other confounders, only insulin and, in women SHBG, were significantly associated, but not adiponectin. In linear regression analyses for covariates of adiponectin in two models comprising 12 variables, insulin and SHBG concentrations were significantly associated in both genders though not BMI. Whereas in men HDL-cholesterol and CRP were covariates of adiponectin (both p<0.01), SHBG and apolipoprotein B positively associated in women (p<0.001), independent of BMI and fasting insulin levels. Conclusions: Relationship between excess adiposity and adiponectin levels is inconsistent in Turkish adults. Independently from obesity and hyperinsulinemia, serum adiponectin discloses significant relationship with inflammatory markers and HDL only in men, not in women in whom it is influenced by SHBG, with consequent attenuation of its anti-inflammatory activities. © Ivyspring International Publisher. All rights reserved.en_US
dc.language.isoenen_US
dc.publisherIvyspring International Publisheren_US
dc.relation.ispartofInternational Journal of Biological Sciencesen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdiponectinen_US
dc.subjectAnti-inflammatory functionen_US
dc.subjectGender differenceen_US
dc.subjectObesityen_US
dc.subjectSex hormone-binding globulinen_US
dc.subjectWaist circumferenceen_US
dc.subjectadiponectinen_US
dc.subjectapolipoprotein Ben_US
dc.subjectC reactive proteinen_US
dc.subjecthigh density lipoprotein cholesterolen_US
dc.subjectinsulinen_US
dc.subjectsex hormone binding globulinen_US
dc.subjectadulten_US
dc.subjectarticleen_US
dc.subjectblood levelen_US
dc.subjectbody massen_US
dc.subjectcholesterol blood levelen_US
dc.subjectconcentration (parameters)en_US
dc.subjectenzyme linked immunosorbent assayen_US
dc.subjectfemaleen_US
dc.subjecthumanen_US
dc.subjectinflammationen_US
dc.subjectinsulin blood levelen_US
dc.subjectlinear regression analysisen_US
dc.subjectmajor clinical studyen_US
dc.subjectmaleen_US
dc.subjectobesityen_US
dc.subjectprotein blood levelen_US
dc.subjectregression analysisen_US
dc.subjectsex differenceen_US
dc.subjectstatistical significanceen_US
dc.subjectwaist circumferenceen_US
dc.titleRelatively high levels of serum adiponectin in obese women, a potential indicator of anti-inflammatory dysfunction: Relation to sex hormone-binding globulinen_US
dc.typeArticleen_US
dc.identifier.volume4en_US
dc.identifier.issue4en_US
dc.identifier.startpage208
dc.identifier.startpage208en_US
dc.identifier.endpage214en_US
dc.authorid0000-0002-5232-7078-
dc.identifier.doi10.7150/ijbs.4.208-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.pmid18695734en_US
dc.identifier.scopus2-s2.0-49849087224en_US
dc.identifier.wosWOS:000260537100003en_US
dc.identifier.scopusqualityQ1-
dc.ownerPamukkale University-
item.languageiso639-1en-
item.openairetypeArticle-
item.grantfulltextopen-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.dept14.02. Internal Medicine-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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