Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/7098
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dc.contributor.authorSaçar, Mustafa-
dc.contributor.authorSaçar, Suzan-
dc.contributor.authorKaleli, İlknur-
dc.contributor.authorCevahir, Nural-
dc.contributor.authorTeke, Zafer-
dc.contributor.authorKavas, Semra Toprak-
dc.contributor.authorAsan, Ali-
dc.date.accessioned2019-08-16T12:15:36Z-
dc.date.available2019-08-16T12:15:36Z-
dc.date.issued2008-
dc.identifier.issn1201-9712-
dc.identifier.urihttps://hdl.handle.net/11499/7098-
dc.identifier.urihttps://doi.org/10.1016/j.ijid.2007.09.017-
dc.description.abstractIntroduction: The treatment of postoperative mediastinitis is very important because of its high morbidity, mortality, and increased hospital stay and hospital costs. The aims of our research were to investigate whether linezolid alone can be an effective treatment agent for methicillin-resistant Staphylococcus aureus (MRSA) mediastinitis, and to determine whether linezolid can provide synergistic activity when given in combination with rifampin. Methods: A partial upper median sternotomy was performed on 70 rats. The animals were divided into seven groups: an uncontaminated control group; an untreated contaminated group; three contaminated groups that received antibiotic therapy with either 25 or 50 mg/kg linezolid twice a day, or rifampin 5 mg/kg twice a day; and two contaminated groups that received a combination therapy consisting of 25 or 50 mg/kg linezolid and rifampin 5 mg/kg twice a day. The antibiotic treatment lasted 7 days. Tissue samples from the upper ends of the sternum and swab specimens of the upper mediastinum were obtained and evaluated microbiologically. Results: The 25-mg/kg dose of linezolid, either alone or combined with rifampin, was not effective in reducing the bacterial counts in mediastinum and sternum. Quantitative bacterial cultures of mediastinum and sternum were significantly lower in the groups receiving 50 mg/kg linezolid alone or in combination with rifampin compared with the control. Adding of rifampin to linezolid therapy did not result in a significant change in bacterial counts versus linezolid alone. Conclusion: A high dose of linezolid should be considered as a possible therapeutic agent for the treatment of post-sternotomy infection caused by MRSA. © 2007 International Society for Infectious Diseases.en_US
dc.language.isoenen_US
dc.relation.ispartofInternational Journal of Infectious Diseasesen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLinezoliden_US
dc.subjectSurgical site infectionen_US
dc.subjectlinezoliden_US
dc.subjectrifampicinen_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectanimal tissueen_US
dc.subjectantibiotic therapyen_US
dc.subjectarticleen_US
dc.subjectbacterial counten_US
dc.subjectbacterium cultureen_US
dc.subjectcombination chemotherapyen_US
dc.subjectcontrolled studyen_US
dc.subjectdrug efficacyen_US
dc.subjectdrug megadoseen_US
dc.subjectdrug potentiationen_US
dc.subjectexperimental studyen_US
dc.subjecthumanen_US
dc.subjectmaleen_US
dc.subjectmediastinitisen_US
dc.subjectmethicillin resistant Staphylococcus aureusen_US
dc.subjectmonotherapyen_US
dc.subjectnonhumanen_US
dc.subjectpostoperative infectionen_US
dc.subjectquantitative analysisen_US
dc.subjectraten_US
dc.subjectsternotomyen_US
dc.subjectsternumen_US
dc.subjecttreatment outcomeen_US
dc.subjectAcetamidesen_US
dc.subjectAnimalsen_US
dc.subjectAnti-Bacterial Agentsen_US
dc.subjectDisease Models, Animalen_US
dc.subjectDose-Response Relationship, Drugen_US
dc.subjectDrug Therapy, Combinationen_US
dc.subjectMaleen_US
dc.subjectMediastinitisen_US
dc.subjectMethicillin Resistanceen_US
dc.subjectOxazolidinonesen_US
dc.subjectRatsen_US
dc.subjectRifampinen_US
dc.subjectStaphylococcal Infectionsen_US
dc.subjectStaphylococcus aureusen_US
dc.subjectSurgical Wound Infectionen_US
dc.titleEfficacy of linezolid in the treatment of mediastinitis due to methicillin-resistant Staphylococcus aureus: an experimental studyen_US
dc.typeArticleen_US
dc.identifier.volume12en_US
dc.identifier.issue4en_US
dc.identifier.startpage396en_US
dc.identifier.endpage401en_US
dc.authorid0000-0001-8764-7701-
dc.authorid0000-0002-8856-7356-
dc.identifier.doi10.1016/j.ijid.2007.09.017-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.pmid18162429en_US
dc.identifier.scopus2-s2.0-44949153693en_US
dc.identifier.wosWOS:000257437900010en_US
dc.identifier.scopusqualityQ1-
dc.ownerPamukkale University-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.grantfulltextopen-
item.languageiso639-1en-
crisitem.author.dept14.01. Surgical Medicine-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.03. Basic Medical Sciences-
crisitem.author.dept14.03. Basic Medical Sciences-
crisitem.author.dept29. Denizli Health Services Vocational School of Higher Education-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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