Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/7108
Title: Endometrioid carcinoma of the endometrium with choriocarcinomatous differentiation: A case report and review of the literature
Authors: Akbulut, M.
Tosun, H.
Soysal, M.E.
Öztekin, Özer
Keywords: Choriocarcinomatous differentiation
Endometrioid adenocarcinoma
hCG
Prognosis
chorionic gonadotropin
abdominal hysterectomy
adult
article
case report
cell differentiation
choriocarcinoma
endometrium biopsy
endometrium carcinoma
female
histopathology
human
immunohistochemistry
lymph node dissection
pelvis lymph node
salpingooophorectomy
treatment outcome
trophoblast
Adult
Carcinoma, Endometrioid
Choriocarcinoma
Chorionic Gonadotropin
Endometrial Neoplasms
Fallopian Tubes
Female
Humans
Hysterectomy
Neoplasms, Multiple Primary
Ovariectomy
Abstract: Objective: An endometrioid adenocarcinoma (EAC) with true trophoblastic differentiation is a rare event with a highly aggressive clinical course. Case: We report an endometrioid adenocarcinoma of the endometrium in which there was a morphologically conventional-appearing EAC component admixed with multinucleated giant cells and large pleomorphic tumor cells that resembled a choriocarcinoma without an elevated serum level of human chorionic gonadotropin (hCG) in a 42-year-old unmarried woman with a history of abnormal uterine bleeding. A total abdominal hysterectomy, bilateral salpingo-oophorectomy, and pelvic lymph node dissection were performed. Histopathologic study of the specimen showed endometrioid adenocarcinoma extended to the deep myometrium with a focus of hemorrhagic and necrotic tumor composed of multinucleated giant cells, large pleomorphic tumor cells, suggesting choriocarcinomatous differentiation (CD). Immunohistochemical studies demonstrated intense reactivity of tumor cells for human chorionic gonadotropin (hCG) confirming the diagnosis. A complete clinical workup ruled out metastatic spread to the brain, lungs, skeleton, or abdomen. The patient was alive with no evidence of disease 6 months later. Conclusion: Although endometrioid adenocarcinoma with choriocarcinomatous differentiation is known to behave in a more aggressive course, this disease may have a good prognosis with a clinically indolent course when it is small, and without elevated serum hCG levels. © 2007 Springer-Verlag.
URI: https://hdl.handle.net/11499/7108
https://doi.org/10.1007/s00404-007-0526-y
ISSN: 0932-0067
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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