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https://hdl.handle.net/11499/7161
Title: | Increased tunel positive cells in CA1, CA2, and CA3 subfields of rat hippocampus due to copper and ethanol co-exposure | Authors: | Tufan, Ahmet Çevik Akdoğan, Ilgaz Turgut, G. Adıgüzel, Esat |
Keywords: | Cell death Copper Ethanol Hippocampus Rat TUNEL alcohol broxuridine copper animal experiment article cell death cell loss controlled study correlation analysis excitotoxicity hippocampus nerve cell nervous system development nick end labeling nonhuman rat regeneration toxicity Animals Bromodeoxyuridine Cell Death Central Nervous System Depressants In Situ Nick-End Labeling Neurons Rats Rats, Wistar Statistics, Nonparametric Trace Elements |
Abstract: | Copper (Cu) is an essential element for life. However, it is toxic at excessive doses, whereas exposure to ethanol (EtOH) has known to cause morphological changes, degeneration, and neuronal loss in central nervous system. A previous investigation by the authors' group showed that Cu and EtOH co-treatment cause severe hippocampal neuronal loss in CA1, CA2, and CA3 subfields of rat hippocampus. This study was designed to analyze the possible mechanism(s) of action of this effect. In addition, the possible neurogenesis in response to a potent neurodegenerative treatment in rat hippocampus was analyzed. Results demonstrated that Cu and EtOH induced neuronal loss in rat hippocampus was in correlation with the increased cell death analyzed on the basis of TdT-mediated dUTP nick end labeling (TUNEL) assay. On the other hand, neuronal regenerative activity was detectable in analyzed CA1, CA2, and CA3 subfields of the rat hippocampus analyzed on the basis of 5-bromo-2'-deoxy- uridine (BrdU) labeling assay; however, this activity in treated group was not significantly different from that of control group. Copyright © 2008 Informa Healthcare USA, Inc. | URI: | https://hdl.handle.net/11499/7161 https://doi.org/10.1080/00207450601046871 |
ISSN: | 0020-7454 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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