Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/7166
Title: Carotid artery intima-media thickness correlates with oxidative stress in chronic haemodialysis patients with accelerated atherosclerosis
Authors: Dursun, Belda
Dursun, E.
Suleymanlar, G.
Ozben, B.
Capraz, I.
Apaydin, A.
Ozben, T.
Keywords: Carotid artery intima media thickness
Chronic haemodialysis patients
Oxidative stress
alpha tocopherol
antioxidant
biological marker
carbonyl derivative
catalase
glutathione peroxidase
nitrate
superoxide dismutase
thiobarbituric acid reactive substance
adult
aged
artery intima
artery media
article
atherosclerosis
brain angiography
carotid artery
clinical article
clinical indicator
controlled study
correlation analysis
disease marker
enzyme blood level
female
hemodialysis
hemodialysis patient
human
kidney failure
linear regression analysis
male
oxidative stress
priority journal
protein carbonylation
statistical significance
uremia
vitamin blood level
Aged
Atherosclerosis
Biological Markers
Carotid Arteries
Case-Control Studies
Catalase
Erythrocytes
Female
Glutathione
Glutathione Peroxidase
Humans
Male
Middle Aged
Nitrates
Nitrites
Oxidative Stress
Renal Dialysis
Sulfhydryl Compounds
Superoxide Dismutase
Thiobarbituric Acid Reactive Substances
Tunica Intima
Uremia
Abstract: Background. Accelerated atherosclerosis is the major cause of mortality in patients on chronic haemodialysis (HD). Increased oxidative stress might be the major factor leading to high cardiovascular mortality rate in HD patients. The aim of our study was to clarify effects of uraemia and dialysis on oxidative stress parameters and explore the relation between oxidative stress markers and carotid artery intima-media thickness (CIMT) as an indicator of atherosclerosis. Methods. Twenty chronic HD patients, 20 predialytic uraemic patients and 20 healthy subjects were included in the study. Serum thiobarbituric acid reactive substances (TBARS), protein carbonyl content (PCO) and nitrite/nitrate levels were determined as oxidative stress markers. Serum vitamin E, plasma sulfhydryl (P-SH), erythrocyte glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activities were measured as antioxidants. CIMT was assessed by carotid artery ultrasonography. Results. Both chronic HD and predialytic uraemic patients had enhanced oxidative stress indicated by higher levels of nitrite/nitrate, TBARS and PCO, and lower levels of P-SH, SOD, CAT and GPx compared to controls. HD patients had significantly higher CIMT and nitrite/nitrate while significantly lower P-SH,vitamin E, SOD, CAT and GPx compared to predialytic uraemic patients. There was a significant positive correlation between CIMT and TBARS (r = 0.38, P = 0.003) and nitrite/nitrate levels (r = 0.41, P = 0.001), while there was a significant negative correlation between CIMT and SOD (r = -0.35, P = 0.01), CAT (r = -0.65, P < 0.001) and P-SH levels (r = -0.50, P < 0.001). A linear regression analysis showed that TBARS were still significantly and positively correlated with CIMT (P = 0.001), while CAT and P-SH were significantly and negatively correlated with CIMT (P = 0.002 and P = 0.048, respectively). Conclusions. HD exacerbates oxidative stress and disturbances in antioxidant enzymes in uraemic patients. We propose that serum TBARS and nitrite/nitrate can be used as positive determinants, while erythrocyte SOD, CAT and P-SH may be used as negative determinants of atherosclerosis assessed by CIMT in uraemic and HD patients. © The Author [2008]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.
URI: https://hdl.handle.net/11499/7166
https://doi.org/10.1093/ndt/gfm906
ISSN: 0931-0509
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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