Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/7194
Title: Simvastatin may improve myocardial perfusion abnormality in slow coronary flow
Authors: Cakmak, M.
Tanriverdi, H.
Cakmak, N.
Evrengul, H.
Cetemen, S.
Kuru, O.
Keywords: Atherosclerosis
Endothelial function
Myocardial ischemia
Slow coronary flow
Statin
TIMI frame count
methoxy isobutyl isonitrile technetium tc 99m
nitrate
simvastatin
adult
angina pectoris
article
blood clot lysis
controlled study
coronary artery blood flow
correlation analysis
female
follow up
heart infarction
heart muscle perfusion
human
major clinical study
male
myocardial disease
priority journal
single drug dose
single photon emission computer tomography
Adult
Angina Pectoris
Blood Chemical Analysis
Blood Flow Velocity
Chest Pain
Cholesterol, HDL
Cholesterol, LDL
Coronary Angiography
Coronary Circulation
Dose-Response Relationship, Drug
Drug Administration Schedule
Female
Follow-Up Studies
Humans
Middle Aged
Probability
Prospective Studies
Risk Assessment
Simvastatin
Statistics, Nonparametric
Tomography, Emission-Computed, Single-Photon
Treatment Outcome
Abstract: Background: The slow coronary flow (SCF) phenomenon is a coronary microvascular disorder characterized by the delayed passage of contrast in the absence of obstructive epicardial coronary disease. Recent studies showed the possible role of endothelial dysfunction, diffuse atherosclerosis and inflammation in the pathogenesis of this phenomenon. We aimed to investigate the effect of statin on myocardial perfusion in patients with SCF. Methods and Results: The study population consisted of 97 patients with SCF. Coronary flow patterns of the cases are determined by thrombolysis in myocardial infarction (TIMI) frame count method. Single-photon emission computed tomographic myocardial perfusion imaging studies and lipid parameters of the patients were obtained before and after 6 months of simvastatin treatment period. During the study, daily single dose of 40 mg simvastatin has been given to each subject. We found a significant positive correlation between mean TIMI frame count and basal reversibility score (r = 0.84, p = 0.0001). In addition, analysis of the reversibility scores demonstrates that simvastatin treatment has significantly improved the myocardial perfusion abnormality at the end of the follow-up period. Conclusion: Present findings allow us to conclude that simvastatin improved myocardial perfusion in patients with SCF. Copyright © 2007 S. Karger AG.
URI: https://hdl.handle.net/11499/7194
https://doi.org/10.1159/000109405
ISSN: 0008-6312
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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