Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/7195
Title: Regulation of the vitamin D receptor and cornifin beta expression in vaginal epithelium of the rats through vitamin D3
Authors: Abban, Gülçin
Yildirim, N.B.
Jetten, A.M.
Keywords: Cornifin ß
Vagina
Vitamin D
Vitamin D receptor
colecalciferol
cornifin
vitamin D receptor
calcitriol
calcitriol receptor
cornifins
membrane protein
animal experiment
animal tissue
article
cell differentiation
control group
controlled study
epithelium cell
female
immunohistochemistry
keratinization
nonhuman
ovariectomy
protein expression
rat
regulatory mechanism
upregulation
vagina epithelium
animal
biosynthesis
cell proliferation
cytology
epithelium
gene expression regulation
metabolism
physiology
vagina
Wistar rat
Animalia
Rattus
Animals
Calcitriol
Cell Proliferation
Epithelial Cells
Epithelium
Female
Gene Expression Regulation
Membrane Proteins
Rats
Rats, Wistar
Receptors, Calcitriol
Abstract: The aim of the present study was to determine the respective role of 1,25-dihydroxyvitamin D3 on vaginal epithelium and 1,25-dihydroxyvitamin D3 receptor expression in ovariectomized rats and vitamin D3 treated rats. Bilateral ovariectomies were performed in 20 mature, non-pregnant Wistar female rats. All the animals were divided into 2 groups consisting of 10 rats each. Group I served as control. In group II, animals were injected intramuscularly with vitamin D3 (50, 00 IU/kg). Two weeks after the injections, vaginas of animals in group I and group II were removed removed and processed for immunohistochemistry. Epithelial differentiation, 1,25-dihydroxyvitamin D3 receptor and cornifin ß expression were investigated in vaginal epithelium of control group (ovariectomized) and vitamin D3 treated rats. Vaginal epithelial cells from vitamin D3 treated animals changed into highly- stratified keratinizing layers. 1,25-dihydroxyvitamin D3 receptor and cornifin ß as a marker of squamous differentiation were present in ovariectomized rats treated with 1,25-dihydroxyvitamin D3. In contrast, cornifin ß and 1,25-dihydroxyvitamin D3 receptor were absent in all layers of vaginal epithelium in control group. We demonstrated for the first time that 1,25-dihydroxyvitamin D3 induced proliferation of vaginal epithelium consistent with the cornifin ß expression and 1,25-dihydroxyvitamin D 3 up-regulated 1,25-dihydroxyvitamin D3 receptor expression in vaginal epithelium. ©2008 European Journal of Histochemistry.
URI: https://hdl.handle.net/11499/7195
ISSN: 1121-760X
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Show full item record



CORE Recommender

SCOPUSTM   
Citations

20
checked on Dec 14, 2024

WEB OF SCIENCETM
Citations

18
checked on Dec 19, 2024

Page view(s)

36
checked on Aug 24, 2024

Google ScholarTM

Check





Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.