Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/7204
Title: Ga-67 uptake: A predictor of post-therapy active residual disease and clinical outcome in patients with diffuse large cell lymphoma
Authors: Sari, Hakan İsmail
Kula, M.
Eser, B.
Kaynar, L.
Altuntaş, F.
Koçyigit, I.
Mavili, E.
Keywords: Gallium citrate
Lymphoma, large B-cell, diffuse
Neoplasm, residual
cyclophosphamide
doxorubicin
gallium 67
prednisone
vincristine
adult
aged
article
cancer patient
cancer relapse
cancer survival
computer assisted tomography
female
histopathology
human
imaging
large cell lymphoma
major clinical study
male
minimal residual disease
outcome assessment
predictor variable
prognosis
risk factor
scoring system
survival rate
treatment response
Abstract: Purpose: Diagnosis and treatment of post-therapy active residual disease (PTARD) is essential in patients with lymphoma. After treatment, Ga-67 scan is considered as a useful technique for monitoring response in these patients. Material and Methods: Between December 1998 and January 2004, 63 patients histopathologically diagnosed with Diffuse Large Cell Lymphoma (DLCL) were studied. Patients were evaluated before and after treatment with a whole body Ga-67 scan in addition to other imaging techniques. International Prognostic Index (IPI), and clinical variables were determined according to criteria reported by the International non-Hodgkin's Lymphoma Prognostic factors Project. Results: Among the patients with positive computed tomography (CT) scan, the 5-year relapse-free and overall survival rates were 70% and 78% for those with negative scans compared with 23% and 35% for gallium-positive patients, respectively (p< 0.004, p<0.008). Furthermore, the 5-year relapse-free and overall survival rates were 92% and %91 for those with negative scans compared with 33% and 40% for gallium-positive patients (p< 0.001, p< 0.004), among the patients with negative CT scan. All patients were divided into two groups according to the IPI index after therapy and the 5-year relapse-free survival rate for negative Ga-67 scan is 75%, as compared with 42% for restaging positive Ga-67 scan (p<0.004) in the patients with low IPI score. Conclusion: Ga-67 scan is capable of detecting PTARD that remains undetected at CT and it appears to be a better predictor of outcome than previously evaluated pretreatment risk factors in patients with DLCL.
URI: https://hdl.handle.net/11499/7204
ISSN: 1300-199X
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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