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https://hdl.handle.net/11499/7218
Title: | Disturbance of pro-oxidative/antioxidative balance in allogeneic peripheral blood stem cell transplantation | Authors: | Sarı, Hakan İsmail Cetin, A. Kaynar, L. Saraymen, R. Hacıoğlu, Sibel K. Ozturk, A. Kocyigit, I. |
Keywords: | Allogeneic stem cell transplantation Free radicals Oxidative stress antioxidant busulfan catalase cyclophosphamide fludarabine free radical glutathione peroxidase malonaldehyde nitric oxide superoxide dismutase acute granulocytic leukemia acute lymphoblastic leukemia adult allogeneic peripheral blood stem cell transplantation antioxidant activity article blood level chronic myeloid leukemia clinical article female graft versus host reaction hematologic malignancy human human tissue male mortality multiple cycle treatment myeloablative conditioning myelofibrosis nonhodgkin lymphoma nonmyeloablative conditioning oxidative stress priority journal statistical analysis Adult Antioxidants Biological Markers Catalase Female Glutathione Peroxidase Graft vs Host Disease Humans Male Malondialdehyde Middle Aged Nitric Oxide Oxidants Oxidative Stress Peripheral Blood Stem Cell Transplantation Superoxide Dismutase Transplantation Conditioning Transplantation, Homologous |
Abstract: | High dose chemotherapy causes increased free radical formation and depletion of tissue antioxidants. Whether allogeneic hematopoietic stem cell transplantation (HSCT) has an effect on oxidative stress is uncertain. The aims of the study were to determine the effect of allogeneic HSCT on plasma concentrations of antioxidants and oxidative stress biomarkers, and to investigate their relationships with graft-versus-host disease (GVHD), conditioning regimens, and transplant-related mortality (TRM) in patients with hematological malignancies. Patients (n=25) undergoing allogeneic HSCT from HLA-matched sibling donors were enrolled in the study. Plasma oxidant and antioxidant status were measured at day -1 before transplantation and 30 days after HSCT. In both myeloablative (n=14) and non-myeloablative (n=11) transplant groups, the mean levels of plasma malondialdehyde (MDA) and nitric oxide (NO) increased after allogeneic HSCT (p <0.01), whereas superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) activities decreased compared with baseline values (p <0.01). No significant relationships were found between either the pretransplant or post-transplant mean levels of the oxidative stress parameters and the existence of graft-versus-host disease (GVHD), the type of conditioning regimen, or transplant related mortality (TRM). This study documents a significant disturbance of pro-oxidative/antioxidative balance in the plasma of patients undergoing allogeneic HSCT regardless of the intensity of the conditioning regimen. © 2008 by the Association of Clinical Scientists, Inc. | URI: | https://hdl.handle.net/11499/7218 | ISSN: | 0091-7370 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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