Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/7218
Title: Disturbance of pro-oxidative/antioxidative balance in allogeneic peripheral blood stem cell transplantation
Authors: Sarı, Hakan İsmail
Cetin, A.
Kaynar, L.
Saraymen, R.
Hacıoğlu, Sibel K.
Ozturk, A.
Kocyigit, I.
Keywords: Allogeneic stem cell transplantation
Free radicals
Oxidative stress
antioxidant
busulfan
catalase
cyclophosphamide
fludarabine
free radical
glutathione peroxidase
malonaldehyde
nitric oxide
superoxide dismutase
acute granulocytic leukemia
acute lymphoblastic leukemia
adult
allogeneic peripheral blood stem cell transplantation
antioxidant activity
article
blood level
chronic myeloid leukemia
clinical article
female
graft versus host reaction
hematologic malignancy
human
human tissue
male
mortality
multiple cycle treatment
myeloablative conditioning
myelofibrosis
nonhodgkin lymphoma
nonmyeloablative conditioning
oxidative stress
priority journal
statistical analysis
Adult
Antioxidants
Biological Markers
Catalase
Female
Glutathione Peroxidase
Graft vs Host Disease
Humans
Male
Malondialdehyde
Middle Aged
Nitric Oxide
Oxidants
Oxidative Stress
Peripheral Blood Stem Cell Transplantation
Superoxide Dismutase
Transplantation Conditioning
Transplantation, Homologous
Abstract: High dose chemotherapy causes increased free radical formation and depletion of tissue antioxidants. Whether allogeneic hematopoietic stem cell transplantation (HSCT) has an effect on oxidative stress is uncertain. The aims of the study were to determine the effect of allogeneic HSCT on plasma concentrations of antioxidants and oxidative stress biomarkers, and to investigate their relationships with graft-versus-host disease (GVHD), conditioning regimens, and transplant-related mortality (TRM) in patients with hematological malignancies. Patients (n=25) undergoing allogeneic HSCT from HLA-matched sibling donors were enrolled in the study. Plasma oxidant and antioxidant status were measured at day -1 before transplantation and 30 days after HSCT. In both myeloablative (n=14) and non-myeloablative (n=11) transplant groups, the mean levels of plasma malondialdehyde (MDA) and nitric oxide (NO) increased after allogeneic HSCT (p <0.01), whereas superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) activities decreased compared with baseline values (p <0.01). No significant relationships were found between either the pretransplant or post-transplant mean levels of the oxidative stress parameters and the existence of graft-versus-host disease (GVHD), the type of conditioning regimen, or transplant related mortality (TRM). This study documents a significant disturbance of pro-oxidative/antioxidative balance in the plasma of patients undergoing allogeneic HSCT regardless of the intensity of the conditioning regimen. © 2008 by the Association of Clinical Scientists, Inc.
URI: https://hdl.handle.net/11499/7218
ISSN: 0091-7370
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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