Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/7233
Title: Oxidative stress parameters in patients with slow coronary flow
Authors: Enli, Yaşar
Turk, M.
Akbay, R.
Evrengul, H.
Tanriverdi, H.
Kuru, O.
Seleci, D.
Keywords: Antioxidants
Oxygen free radicals
Slow coronary flow
catalase
erythrocyte superoxide dismutase
glutathione
malonaldehyde
myeloperoxidase
reactive oxygen metabolite
superoxide dismutase
unclassified drug
adult
analytical parameters
article
blood flow velocity
cardiovascular risk
coronary artery blood flow
coronary artery disease
enzyme blood level
female
hemoglobin blood level
human
lipid peroxidation
major clinical study
male
oxidative stress parameter
pathogenesis
risk assessment
risk factor
slow coronary artery blood flow
middle aged
oxidative stress
Blood Flow Velocity
Coronary Circulation
Female
Humans
Male
Middle Aged
Oxidative Stress
Abstract: Introduction: We investigated the probable role of free-radical damage in the pathogenesis of slow coronary flow (SCF) by using oxidative stress parameters. Methods: Sixty-four patients with angiographically proven SCF and 63 patients with normal coronary flow (NCF) pattern with similar risk profiles were enrolled in this study. We measured erythrocyte superoxide dismutase (SOD), reduced glutathione (GSH), serum malondialdehyde (MDA), catalase and myeloperoxidase (MPO) levels in all subjects. Results: There were statistically significant differences in the levels of erythrocyte SOD, GSH and serum MDA between the 2 groups. Serum MDA (P = 0.003) and erythrocyte SOD levels (P = 0.0001) were increased in the SCF group. The level of erythrocyte GSH (P = 0.010) was lower in patients with SCF. There were no differences between the groups' serum catalase (P = 0.682) and MPO levels (P = 0.070). Conclusion: Our data showed that in patients with SCF, serum MDA and erythrocyte SOD levels were increased while erythrocyte GSH levels were decreased significantly, compared with NCF patients. These results indicate that free-radical damage may play a role in the pathogenesis of SCF. © Springer Healthcare Communications 2008.
URI: https://hdl.handle.net/11499/7233
https://doi.org/10.1007/s12325-008-0011-4
ISSN: 0741-238X
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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