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https://hdl.handle.net/11499/7318
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zencir, S. | - |
dc.contributor.author | Alptekin, D. | - |
dc.contributor.author | Celiktas, M. | - |
dc.contributor.author | Canturk, P. | - |
dc.contributor.author | Colak, D. | - |
dc.contributor.author | Caner, Vildan. | - |
dc.contributor.author | Luleyap, U.H. | - |
dc.date.accessioned | 2019-08-16T12:19:46Z | |
dc.date.available | 2019-08-16T12:19:46Z | |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0939-5075 | - |
dc.identifier.uri | https://hdl.handle.net/11499/7318 | - |
dc.identifier.uri | https://doi.org/10.1515/znc-2008-9-1026 | - |
dc.description.abstract | Cytochrome P450 (CYP) is a heme-containing enzyme superfamily metabolizing a wide variety of xenobiotics, including drugs and carcinogens. The majority of CYP genes are expressed in the liver, however, some CYP isoforms are also reported for a number of extra hepatic tissues. We analyzed Cytochrome P450-2A6, -3A5 and -4B1 mRNAs using real-time reverse-transcriptase polymerase chain reaction (RT-PCR) in a total of 21 homogenized prostate tissues with or without malignancy. We detected a consistent expression of CYP2A6 and CYP3A5 in all, and of CYP4B1 in some (11/21) of the samples at mRNA level. Neither the histopathological status nor the smoking habit of the individuals affected CYP4B1 expression. Our results reflect possible roles for these particular CYPs in therapy and protection of prostate tissue. © 2008 Verlag der Zeitschrift für Naturforschung. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Verlag der Zeitschrift fur Naturforschung | en_US |
dc.relation.ispartof | Zeitschrift fur Naturforschung - Section C Journal of Biosciences | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Cytochrome P450 expression | en_US |
dc.subject | Prostate | en_US |
dc.title | Detection of cytochrome P450-2A6, -3A5 and -4B1 with real-time polymerase chain reaction in prostate tissue | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 63 | en_US |
dc.identifier.issue | 9-10 | en_US |
dc.identifier.startpage | 780 | |
dc.identifier.startpage | 780 | en_US |
dc.identifier.endpage | 784 | en_US |
dc.authorid | 0000000309809335 | - |
dc.identifier.doi | 10.1515/znc-2008-9-1026 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.scopus | 2-s2.0-56249128224 | en_US |
dc.identifier.wos | WOS:000260706300026 | en_US |
dc.identifier.scopusquality | Q3 | - |
dc.owner | Pamukkale University | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en | - |
item.openairetype | Article | - |
item.fulltext | No Fulltext | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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