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https://hdl.handle.net/11499/7325
Title: | Are uremia, diabetes, and atherosclerosis linked with impaired antioxidant mechanisms? | Authors: | Dursun, Belda. Dursun, E. Capraz, I. Ozben, T. Apaydin, A. Suleymanlar, G. |
Keywords: | Antioxidant mechanisms Atherosclerosis Uremia catalase glutathione glutathione peroxidase superoxide dismutase thiol antioxidant thiol derivative adult antioxidant activity artery intima proliferation article atherosclerosis controlled study diabetes mellitus diabetic patient disease severity echography female human kidney disease lipid peroxidation major clinical study male oxidative stress risk factor uremia carotid artery carotid artery disease diabetic angiopathy diabetic nephropathy metabolism middle aged physiology Antioxidants Carotid Arteries Carotid Artery Diseases Diabetic Angiopathies Diabetic Nephropathies Female Humans Male Middle Aged Oxidative Stress Risk Factors Sulfhydryl Compounds |
Publisher: | BMJ Publishing Group | Abstract: | Background: Oxidative stress is a new risk factor for atherosclerosis. Increased oxidative stress in hemodialysis (HD) patients may arise from uremia-associated metabolic/ humoral abnormalities and bioincompatibility of dialysis. Patients with diabetes mellitus (DM) may be subject to an additional risk. Respective influences of uremia, diabetes, and HD duration in accelerated atherosclerosisa nd oxidative stress have not been clarified yet. Methods: The study was performed on 24 nondiabetic HD patients, 23 diabetic HD patients, 20 stages 3 to 4 chronic kidney disease patients, and 21 diabetic patients without overt nephropathy. Carotid intima-media thickness, a surrogate of atherosclerosis, was measured by high-resolution B-mode ultrasonography. Oxidant status was determined by lipid peroxidation as expressed by malondialdehyde (MDA); antioxidant status was determined by superoxide dismutase, catalase, glutathione peroxidase, reduced intracellular glutathione, and plasma thiol. Results: Intima-media thi kness (IMT) was higher in patients undergoing HD but not different between nondiabetic HD patients and diabetic HD patients. No correlation was found between the duration of HD and intima-media thickness. Antioxidants were generally lower in HD patients. Intima-media thickness was positively correlated with MDA and negatively correlated with plasma thiol. Among other risk factors, only age was correlated with intima-media thickness. Conclusions: Increased carotid IMT in HD patients is independent of duration of HD or diabetes status. Age and MDA are the significant predictors of carotid IMT. Increased oxidative stress due to impaired antioxidant mechanisms, particularly reduced plasma thiol redox potential, may account for accelerated atherosclerosis in high-risk patients with chronic kidney failure and/or DM. ©2008 American Federation for Medical Research. | URI: | https://hdl.handle.net/11499/7325 https://doi.org/10.2310/JIM.0b013e3181641ce3 |
ISSN: | 1708-8267 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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