Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/7331
Full metadata record
DC FieldValueLanguage
dc.contributor.authorAyada, C.-
dc.contributor.authorToru, Ü.-
dc.contributor.authorGenç, O.-
dc.contributor.authorYerlikaya, A.-
dc.contributor.authorŞahin, S.-
dc.contributor.authorTurgut, Sebahat-
dc.contributor.authorTurgut, Günfer-
dc.date.accessioned2019-08-16T12:29:19Z
dc.date.available2019-08-16T12:29:19Z
dc.date.issued2014-
dc.identifier.issn1676-5680-
dc.identifier.urihttps://hdl.handle.net/11499/7331-
dc.identifier.urihttps://doi.org/10.4238/2014.December.12.4-
dc.description.abstractChronic obstructive pulmonary disease (COPD) is characterized by progressive airflow obstruction that occurs as a result of the normal inflammatory process to protect against harmful irritants and chemicals. Another physiological regulatory process, the renin angiotensin system (RAS), plays an important role in the pathology of many diseases. Angiotensin converting enzyme (ACE) is a key enzyme of RAS. We investigated the frequency of the ACE gene I/D polymorphism in patients with COPD in Turkey. This study was performed on 47 unrelated patients with COPD and 64 healthy subjects. DNA samples were isolated from peripheral blood, and ACE DNA was amplified by polymerase chain reaction. The frequencies of ACE genotypes were 27.7, 55.3, and 17% for DD, ID, and II in the COPD group, respectively, and 43.8, 43.8, and 12.4% in the control group. There was no statistically significant difference between groups (?2 = 3.078; df = 2; P = 0.220). The distributions of ACE gene D alleles were 38.2% (N = 52) in the COPD group and 61.8% (N = 84) in the control group; and those of I alleles were 48.8% (N = 42) in the COPD group and 51.2% (N = 44) in the control group. There was no statistically significant difference between groups for allele frequency (?2 = 2.419; df = 2; P = 0.120). We believe these results can be useful for large-scale population genetic research considering the frequency of the ACE gene variation in COPD patients in the Turkish population. © FUNPEC-RP.en_US
dc.language.isoenen_US
dc.publisherFundacao de Pesquisas Cientificas de Ribeirao Pretoen_US
dc.relation.ispartofGenetics and Molecular Researchen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAngiotensin converting enzymeen_US
dc.subjectChronic obstructive pulmonary diseaseen_US
dc.subjectRenin angiotensin systemen_US
dc.subjectTurkish populationen_US
dc.subjectdipeptidyl carboxypeptidaseen_US
dc.subjectgenomic DNAen_US
dc.subjectACE protein, humanen_US
dc.subjectACE geneen_US
dc.subjectalleleen_US
dc.subjectArticleen_US
dc.subjectblood samplingen_US
dc.subjectchronic obstructive lung diseaseen_US
dc.subjectclinical articleen_US
dc.subjectcontrolled studyen_US
dc.subjectDNA determinationen_US
dc.subjectDNA isolationen_US
dc.subjectgene expressionen_US
dc.subjectgene frequencyen_US
dc.subjectgene functionen_US
dc.subjectgene identificationen_US
dc.subjectgenetic polymorphismen_US
dc.subjectgenetic risken_US
dc.subjectgenetic variabilityen_US
dc.subjectgenotypeen_US
dc.subjectgeographic distributionen_US
dc.subjectheterozygosityen_US
dc.subjecthomozygosityen_US
dc.subjecthumanen_US
dc.subjectindel mutationen_US
dc.subjectpathophysiologyen_US
dc.subjectpolymerase chain reactionen_US
dc.subjectpopulation geneticsen_US
dc.subjectrisk factoren_US
dc.subjectTurk (people)en_US
dc.subjectTurkey (republic)en_US
dc.subjectgenetic associationen_US
dc.subjectgenetic predispositionen_US
dc.subjectgeneticsen_US
dc.subjectpathologyen_US
dc.subjectrenin angiotensin aldosterone systemen_US
dc.subjectTurkeyen_US
dc.subjectGene Frequencyen_US
dc.subjectGenetic Association Studiesen_US
dc.subjectGenetic Predisposition to Diseaseen_US
dc.subjectHumansen_US
dc.subjectINDEL Mutationen_US
dc.subjectPeptidyl-Dipeptidase Aen_US
dc.subjectPulmonary Disease, Chronic Obstructiveen_US
dc.subjectRenin-Angiotensin Systemen_US
dc.subjectRisk Factorsen_US
dc.titleEvaluation of whether the ACE gene I/D polymorphism constitutes a risk factor for chronic obstructive pulmonary disease in the Turkish populationen_US
dc.typeArticleen_US
dc.identifier.volume13en_US
dc.identifier.issue4en_US
dc.identifier.startpage10427
dc.identifier.startpage10427en_US
dc.identifier.endpage10433en_US
dc.identifier.doi10.4238/2014.December.12.4-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.pmid25511026en_US
dc.identifier.scopus2-s2.0-84917706717en_US
dc.identifier.wosWOS:000350229200076en_US
dc.identifier.scopusqualityQ3-
dc.ownerPamukkale University-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextopen-
item.languageiso639-1en-
item.openairetypeArticle-
item.fulltextWith Fulltext-
item.cerifentitytypePublications-
crisitem.author.dept14.03. Basic Medical Sciences-
crisitem.author.dept14.03. Basic Medical Sciences-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Files in This Item:
File SizeFormat 
gmr5287.pdf386.46 kBAdobe PDFView/Open
Show simple item record



CORE Recommender

SCOPUSTM   
Citations

10
checked on Dec 21, 2024

WEB OF SCIENCETM
Citations

9
checked on Dec 19, 2024

Page view(s)

36
checked on Aug 24, 2024

Download(s)

24
checked on Aug 24, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.