Please use this identifier to cite or link to this item:
https://hdl.handle.net/11499/7350
Title: | MDR-1 gene C/T polymorphism in COPD: Data from Aegean part of Turkey | Authors: | Toru, Ü. Ayada, C. Genç, O. Turgut, Sebahat Turgut, G. Bulut, İ. |
Keywords: | Chronic obstructive pulmonary disease Multi-drug resistant-1 gene Polymorphism Article chromosome 7 chronic obstructive lung disease clinical article controlled study DNA extraction DNA polymorphism gene gene amplification gene frequency genotype human multi drug resistant 1 gene polymerase chain reaction Turkey (republic) |
Publisher: | E-Century Publishing Corporation | Abstract: | Results: The frequencies of MDR-1 genotypes were found 17.0% for CC, 51.1% for CT and 31.9% for TT in the COPD group and 39.1% for CC, 53.1% for CT and 7.8% for TT in the control group. The distribution of MDR-1 gene C alleles were found 32.3% in COPD group and 67.7% in control group; T alleles were found 55.1% in COPD group and 44.9% in control group. There was statistically significant difference between the groups for genotype and allele frequency of MDR-1 gene (P = 0.001). Conclusion: TT genotype of MDR-1 gene was significantly more frequent in COPD patients. MDR-1 gene C/T polymorphism may play a role in COPD development. Objective: Genetic factors, in addition to oxidative stress factors, have been implicated in the development of chronic obstructive pulmonary disease (COPD). Multi-drug resistant-1 (MDR-1) is a gene located on chromosome 7 and the products of this gene protect lung tissue from oxidative stress. We searched the frequency of MDR-1 gene C/T polymorphism in patients with COPD and aimed to explain the association between MDR-1 gene and COPD development. Methods: 47 patients with COPD and 64 healthy control participants were placed in this study. DNAs were extracted from blood samples and MDR-1 amplification of DNA was performed using polymerase chain reaction and enzyme digestion techniques. © 2014, E-Century Publishing Corporation. All rights reserved. |
URI: | https://hdl.handle.net/11499/7350 | ISSN: | 1940-5901 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
Show full item record
CORE Recommender
SCOPUSTM
Citations
10
checked on Oct 13, 2024
WEB OF SCIENCETM
Citations
7
checked on Nov 13, 2024
Page view(s)
52
checked on Aug 24, 2024
Google ScholarTM
Check
Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.