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Title: | MDR-1 gene C/T polymorphism in COPD: Data from Aegean part of Turkey | Authors: | Toru, Ü. Ayada, C. Genç, O. Turgut, Sebahat Turgut, G. Bulut, İ. |
Keywords: | Chronic obstructive pulmonary disease Multi-drug resistant-1 gene Polymorphism Article chromosome 7 chronic obstructive lung disease clinical article controlled study DNA extraction DNA polymorphism gene gene amplification gene frequency genotype human multi drug resistant 1 gene polymerase chain reaction Turkey (republic) |
Publisher: | E-Century Publishing Corporation | Abstract: | Results: The frequencies of MDR-1 genotypes were found 17.0% for CC, 51.1% for CT and 31.9% for TT in the COPD group and 39.1% for CC, 53.1% for CT and 7.8% for TT in the control group. The distribution of MDR-1 gene C alleles were found 32.3% in COPD group and 67.7% in control group; T alleles were found 55.1% in COPD group and 44.9% in control group. There was statistically significant difference between the groups for genotype and allele frequency of MDR-1 gene (P = 0.001). Conclusion: TT genotype of MDR-1 gene was significantly more frequent in COPD patients. MDR-1 gene C/T polymorphism may play a role in COPD development. Objective: Genetic factors, in addition to oxidative stress factors, have been implicated in the development of chronic obstructive pulmonary disease (COPD). Multi-drug resistant-1 (MDR-1) is a gene located on chromosome 7 and the products of this gene protect lung tissue from oxidative stress. We searched the frequency of MDR-1 gene C/T polymorphism in patients with COPD and aimed to explain the association between MDR-1 gene and COPD development. Methods: 47 patients with COPD and 64 healthy control participants were placed in this study. DNAs were extracted from blood samples and MDR-1 amplification of DNA was performed using polymerase chain reaction and enzyme digestion techniques. © 2014, E-Century Publishing Corporation. All rights reserved. |
URI: | https://hdl.handle.net/11499/7350 | ISSN: | 1940-5901 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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