Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/7350
Title: MDR-1 gene C/T polymorphism in COPD: Data from Aegean part of Turkey
Authors: Toru, Ü.
Ayada, C.
Genç, O.
Turgut, Sebahat
Turgut, G.
Bulut, İ.
Keywords: Chronic obstructive pulmonary disease
Multi-drug resistant-1 gene
Polymorphism
Article
chromosome 7
chronic obstructive lung disease
clinical article
controlled study
DNA extraction
DNA polymorphism
gene
gene amplification
gene frequency
genotype
human
multi drug resistant 1 gene
polymerase chain reaction
Turkey (republic)
Publisher: E-Century Publishing Corporation
Abstract: Results: The frequencies of MDR-1 genotypes were found 17.0% for CC, 51.1% for CT and 31.9% for TT in the COPD group and 39.1% for CC, 53.1% for CT and 7.8% for TT in the control group. The distribution of MDR-1 gene C alleles were found 32.3% in COPD group and 67.7% in control group; T alleles were found 55.1% in COPD group and 44.9% in control group. There was statistically significant difference between the groups for genotype and allele frequency of MDR-1 gene (P = 0.001).
Conclusion: TT genotype of MDR-1 gene was significantly more frequent in COPD patients. MDR-1 gene C/T polymorphism may play a role in COPD development.
Objective: Genetic factors, in addition to oxidative stress factors, have been implicated in the development of chronic obstructive pulmonary disease (COPD). Multi-drug resistant-1 (MDR-1) is a gene located on chromosome 7 and the products of this gene protect lung tissue from oxidative stress. We searched the frequency of MDR-1 gene C/T polymorphism in patients with COPD and aimed to explain the association between MDR-1 gene and COPD development.
Methods: 47 patients with COPD and 64 healthy control participants were placed in this study. DNAs were extracted from blood samples and MDR-1 amplification of DNA was performed using polymerase chain reaction and enzyme digestion techniques. © 2014, E-Century Publishing Corporation. All rights reserved.
URI: https://hdl.handle.net/11499/7350
ISSN: 1940-5901
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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