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Title: | The effects of resveratrol on hyperoxia-induced lung injury in neonatal rats | Authors: | Özdemir, Özmert Muhammet Ali Gözkeser, E. Bir, Ferda Yenisey, Ç. |
Keywords: | hyperoxia-induced lung injury nitric oxide oxidative stress resveratrol glutathione immunoglobulin enhancer binding protein smooth muscle actin superoxide dismutase tumor necrosis factor alpha antioxidant nonsteroid antiinflammatory agent stilbene derivative animal experiment animal model animal tissue antiinflammatory activity antioxidant activity Article biochemistry body weight controlled study enzyme activity histopathology hyperoxia immunohistochemistry lung fibrosis lung injury lung parenchyma newborn nonhuman pathogenesis rat animal Bronchopulmonary Dysplasia disease model human lung metabolism prematurity Wistar rat Animals Animals, Newborn Anti-Inflammatory Agents, Non-Steroidal Antioxidants Disease Models, Animal Humans Hyperoxia Infant, Newborn Infant, Premature Lung Lung Injury Rats, Wistar Stilbenes |
Publisher: | Elsevier (Singapore) Pte Ltd | Abstract: | Background: Bronchopulmonary dysplasia (BPD) is a chronic lung disease that causes significant morbidity and mortality in premature infants. Inflammation and oxidative injury play an important role in the pathogenesis of BPD. Resveratrol is an antioxidant and anti-inflammatory agent. In this study, the histopathological and biochemical effects of resveratrol on a hyperoxia-induced lung injury model in newborn rats were investigated. Methods: The experiment was performed on newborn rat pups from the 3rd to 13th postnatal day and they were randomly divided into four groups: Group 1 (air-exposed + saline, n Z 10), Group 2 (air-exposed + resveratrol, n Z 11), Group 3 (hyperoxia-exposed + saline, n Z 6) and Group 4 (hyperoxia-exposed + resveratrol, n Z 7). Resveratrol was administered (30 mg/kg/day) intraperitoneally. The histopathological effects of resveratrol on lung tissue were assessed by alveolar surface area, fibrosis, and smooth muscle actin (SMA) score, and the biochemical effects on lung tissue were assessed by glutathione (GSH), superoxide dismutase (SOD), nitric oxide (NO), tumor necrosis factor-? (TNF-?), and nuclear factor kappa B (NF-?B) levels. Results: The alveolar surface area, fibrosis, SMA score, and NO levels were found to be significantly higher in Group 3 compared with Group 1 (p < 0.05). In addition, it was found that resveratrol treatment significantly reduced the SMA score and the NO and TNF-? levels, and increased the GSH and SOD levels in the hyperoxia group (p < 0.05). Conclusion: This experimental study showed that oxidative stress and NO contributed to the pathogenesis of hyperoxia-induced lung injury, and that resveratrol had a preventive effect on hyperoxic lung injury through its anti-inflammatory and antioxidant properties. © 2014, Taiwan Pediatric Association. Published by Elsevier Taiwan LLC. All rights reserved. |
URI: | https://hdl.handle.net/11499/7361 https://doi.org/10.1016/j.pedneo.2013.11.004 |
ISSN: | 1875-9572 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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