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https://hdl.handle.net/11499/7403
Title: | The investigation of the possible relationship between Coxsackie viruses and pemphigus | Authors: | Kaçar, Nida Cevahir, Nural Demirkan, Neşe Şanli, B. |
Keywords: | coxsackie virus and adenovirus receptor like membrane protein immunoglobulin G immunoglobulin M virus antibody virus RNA adolescent adult aged biopsy complication Coxsackie virus infection enzyme linked immunosorbent assay female genetics human immunology male metabolism middle aged pathology pemphigus polymerase chain reaction skin very elderly virology Adolescent Adult Aged Aged, 80 and over Antibodies, Viral Biopsy Coxsackie and Adenovirus Receptor-Like Membrane Protein Coxsackievirus Infections Enzyme-Linked Immunosorbent Assay Female Humans Immunoglobulin G Immunoglobulin M Male Middle Aged Pemphigus Polymerase Chain Reaction RNA, Viral Skin |
Abstract: | Background: Pemphigus is a group of autoimmune bullous diseases on which the etiopathogenesis of several viruses has been blamed. Coxsackie viruses (CVs) are the causative agents of hand, foot, and mouth disease, and herpangina, which have been strongly associated with several autoimmune diseases. The onset of pemphigus after CV infection and cephalosporin use has been reported. Objective: To detect the presence of CV in patients with pemphigus. Materials and methods: Reverse transcriptase-polymerase chain reaction analysis for CV RNA sequences and immunohistochemical staining for the CV and adenovirus receptor expression were performed on patient skin samples. CV-IgM and -IgG serum levels were analyzed. Results: Thirty-two patients and 40 controls were investigated. Neither the CV and adenovirus receptor expression nor CV RNA sequences was established in the skin samples of patients. The ratio of CV-IgG positivity was higher in patients (12.5%) than in the controls (5%; P > 0.05). Conclusion: Our preliminary results indicate that the viral genome of CV does not become persistent in the skin. Further studies with a larger number of cases are needed to clarify the place of CVs in the etiopathogenesis of pemphigus. © 2013 The International Society of Dermatology. | URI: | https://hdl.handle.net/11499/7403 https://doi.org/10.1111/j.1365-4632.2012.05699.x |
ISSN: | 0011-9059 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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