Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/7403
Title: The investigation of the possible relationship between Coxsackie viruses and pemphigus
Authors: Kaçar, Nida
Cevahir, Nural
Demirkan, Neşe
Şanli, B.
Keywords: coxsackie virus and adenovirus receptor like membrane protein
immunoglobulin G
immunoglobulin M
virus antibody
virus RNA
adolescent
adult
aged
biopsy
complication
Coxsackie virus infection
enzyme linked immunosorbent assay
female
genetics
human
immunology
male
metabolism
middle aged
pathology
pemphigus
polymerase chain reaction
skin
very elderly
virology
Adolescent
Adult
Aged
Aged, 80 and over
Antibodies, Viral
Biopsy
Coxsackie and Adenovirus Receptor-Like Membrane Protein
Coxsackievirus Infections
Enzyme-Linked Immunosorbent Assay
Female
Humans
Immunoglobulin G
Immunoglobulin M
Male
Middle Aged
Pemphigus
Polymerase Chain Reaction
RNA, Viral
Skin
Abstract: Background: Pemphigus is a group of autoimmune bullous diseases on which the etiopathogenesis of several viruses has been blamed. Coxsackie viruses (CVs) are the causative agents of hand, foot, and mouth disease, and herpangina, which have been strongly associated with several autoimmune diseases. The onset of pemphigus after CV infection and cephalosporin use has been reported. Objective: To detect the presence of CV in patients with pemphigus. Materials and methods: Reverse transcriptase-polymerase chain reaction analysis for CV RNA sequences and immunohistochemical staining for the CV and adenovirus receptor expression were performed on patient skin samples. CV-IgM and -IgG serum levels were analyzed. Results: Thirty-two patients and 40 controls were investigated. Neither the CV and adenovirus receptor expression nor CV RNA sequences was established in the skin samples of patients. The ratio of CV-IgG positivity was higher in patients (12.5%) than in the controls (5%; P > 0.05). Conclusion: Our preliminary results indicate that the viral genome of CV does not become persistent in the skin. Further studies with a larger number of cases are needed to clarify the place of CVs in the etiopathogenesis of pemphigus. © 2013 The International Society of Dermatology.
URI: https://hdl.handle.net/11499/7403
https://doi.org/10.1111/j.1365-4632.2012.05699.x
ISSN: 0011-9059
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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