Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/7407
Title: Intravenous paracetamol versus dexketoprofen versus morphine in acute mechanical low back pain in the emergency department: A randomised double-blind controlled trial
Authors: Eken, C.
Serinken, Mustafa
Elicabuk, H.
Uyanik, E.
Erdal, M.
Keywords: analgesia/pain control
emergency departments
treatment
Acetaminophen
Acute Disease
Adult
Analgesics
Analysis of Variance
Anti-Inflammatory Agents, Non-Steroidal
Double-Blind Method
Emergency Service, Hospital
Female
Humans
Injections, Intravenous
Ketoprofen
Low Back Pain
Male
Middle Aged
Morphine
Tromethamine
Abstract: Study objective The objective of this study was to determine the analgesic efficacy and safety of intravenous, single-dose paracetamol versus dexketoprofen versus morphine in patients presenting with mechanical low back pain (LBP) to the emergency department (ED). Methods This randomised double-blind study compared the efficacy of intravenous 1 gm paracetamol, 50 mg dexketoprofen and 0.1 mg/kg morphine in patients with acute mechanical LBP. Visual analogue scale (VAS) was used for pain measurement at baseline, after 15 and after 30 min. Results A total of 874 patients were eligible for the study, and 137 of them were included in the final analysis: 46 patients from the paracetamol group, 46 patients in the dexketoprofen group and 45 patients in the morphine group. The mean age of study subjects was 31.5±9.5 years, and 60.6% (n=83) of them were men. The median reduction in VAS score at the 30th minute for the paracetamol group was 65 mm (95% CI 58 to 72), 67 mm (95% CI 60 to 73) for the morphine group and 58 mm (95% CI 50 to 64) for the dexketoprophen group. Although morphine was not superior to paracetamol at 30 min (difference: 3.8±4.9 (95% CI -6 to 14), the difference between morphine and dexketoprofen in reducing pain was 11.2±4.7 (95% CI 2 to 21). At least one adverse effect occurred in 8.7% (n=4) of the cases in the paracetamol group, 15.5% (n=7) of the morphine group, and 8.7% (n=4) of the dexketoprophen group (p=0.482). Conclusions Intravenous paracetamol, dexketoprofen and morphine are not superior to each other for the treatment of mechanical LBP in ED.
URI: https://hdl.handle.net/11499/7407
https://doi.org/10.1136/emermed-2012-201670
ISSN: 1472-0205
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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